The morphological and functional diversity of apical microvilli

M Sharkova, E Chow, T Erickson… - Journal of …, 2023 - Wiley Online Library
Sensory neurons use specialized apical processes to perceive external stimuli and monitor
internal body conditions. The apical apparatus can include cilia, microvilli, or both, and is …

Types of inheritance and genes associated with familial Meniere disease

AM Parra-Perez, JA Lopez-Escamez - … of the Association for Research in …, 2023 - Springer
Meniere disease (MD) is a rare disorder of the inner ear defined by sensorineural hearing
loss (SNHL) associated with episodes of vertigo and tinnitus. The phenotype is variable, and …

The cochlear matrisome: Importance in hearing and deafness

MT Pressé, B Malgrange, L Delacroix - Matrix Biology, 2024 - Elsevier
The extracellular matrix (ECM) consists in a complex meshwork of collagens, glycoproteins,
and proteoglycans, which serves a scaffolding function and provides viscoelastic properties …

Stress reactivity, susceptibility to hypertension, and differential expression of genes in hypertensive compared to normotensive patients

D Oshchepkov, I Chadaeva, R Kozhemyakina… - International Journal of …, 2022 - mdpi.com
Although half of hypertensive patients have hypertensive parents, known hypertension-
related human loci identified by genome-wide analysis explain only 3% of hypertension …

Functional development and regeneration of hair cells in the zebrafish lateral line

K Hardy, AE Amariutei, F De Faveri… - The Journal of …, 2021 - Wiley Online Library
Key points We investigated hair‐cell regeneration in the zebrafish lateral line following the
application of the ototoxic compound copper. In early‐larval zebrafish (< 10 days post …

AAV-mediated rescue of Eps8 expression in vivo restores hair-cell function in a mouse model of recessive deafness

JY Jeng, AJ Carlton, RJ Goodyear, C Chinowsky… - … Therapy-Methods & …, 2022 - cell.com
The transduction of acoustic information by hair cells depends upon mechanosensitive
stereociliary bundles that project from their apical surface. Mutations or absence of the …

Unloading outer hair cell bundles in vivo does not yield evidence of spontaneous oscillations in the mouse cochlea

PM Quiñones, SWF Meenderink, BE Applegate… - Hearing research, 2022 - Elsevier
Along with outer hair cell (OHC) somatic electromotility as the actuator of cochlear
amplification, active hair bundle motility may be a complementary mechanism in the …

Hearing loss in exfoliation syndrome: systematic review and meta‐analysis

MC Shih, TM Gordis, PR Lambert… - The …, 2023 - Wiley Online Library
Objective To determine if exfoliation syndrome (XFS) is associated with hearing loss (HL) or
vestibular dysfunction. Data Sources PubMed, Scopus, CINAHL, and Cochrane Library …

Gating-spring stiffness increases outer-hair-cell bundle stiffness, damping, and receptor current

Z Zhu, W Reid, D Ó Maoiléidigh - Scientific Reports, 2024 - nature.com
In our ears, outer-hair-cell bundles (OHBs) convert sound-induced forces into receptor
currents that drive cochlear amplification, the process responsible for the micropascal-scale …

[HTML][HTML] Cubic and quadratic distortion products in vibrations of the mouse cochlear apex

JB Dewey - JASA Express Letters, 2022 - pubs.aip.org
When the ear is stimulated by two tones presented at frequencies f 1 and f 2, nonlinearity in
the cochlea's vibratory response leads to the generation of distortion products (DPs), with …