The central role of cytochrome P450 in xenobiotic metabolism—a brief review on a fascinating enzyme family
F Esteves, J Rueff, M Kranendonk - Journal of xenobiotics, 2021 - mdpi.com
Human Cytochrome P450 (CYP) enzymes constitute a superfamily of membrane-bound
hemoproteins that are responsible for the metabolism of a wide variety of clinically …
hemoproteins that are responsible for the metabolism of a wide variety of clinically …
High-resolution QTL mapping in Tetranychus urticae reveals acaricide-specific responses and common target-site resistance after selection by different METI-I …
Arthropod herbivores cause dramatic crop losses, and frequent pesticide use has led to
widespread resistance in numerous species. One such species, the two-spotted spider mite …
widespread resistance in numerous species. One such species, the two-spotted spider mite …
Bioactivity of curcumin on the cytochrome P450 enzymes of the steroidogenic pathway
PR Castaño, S Parween, AV Pandey - International journal of molecular …, 2019 - mdpi.com
Turmeric, a popular ingredient in the cuisine of many Asian countries, comes from the roots
of the Curcuma longa and is known for its use in Chinese and Ayurvedic medicine. Turmeric …
of the Curcuma longa and is known for its use in Chinese and Ayurvedic medicine. Turmeric …
Finding new molecular targets of familiar natural products using in silico target prediction
F Mayr, G Möller, U Garscha, J Fischer… - International journal of …, 2020 - mdpi.com
Natural products comprise a rich reservoir for innovative drug leads and are a constant
source of bioactive compounds. To find pharmacological targets for new or already known …
source of bioactive compounds. To find pharmacological targets for new or already known …
Insight into the structural and functional analysis of the impact of missense mutation on cytochrome P450 oxidoreductase
R Kumar, M Jayaraman, K Ramadas… - Journal of Molecular …, 2020 - Elsevier
Cytochrome P450 oxidoreductase (POR) is a steroidogenic and drug-metabolizing enzyme.
It helps in the NADPH dependent transfer of electrons to cytochrome P450 (CYP) enzymes …
It helps in the NADPH dependent transfer of electrons to cytochrome P450 (CYP) enzymes …
Synthesis and structure–activity relationships of novel non-steroidal CYP17A1 inhibitors as potential prostate cancer agents
TM Wróbel, O Rogova, K Sharma… - Biomolecules, 2022 - mdpi.com
Twenty new compounds, targeting CYP17A1, were synthesized, based on our previous
work on a benzimidazole scaffold, and their biological activity evaluated. Inhibition of …
work on a benzimidazole scaffold, and their biological activity evaluated. Inhibition of …
Differential effects of variations in human P450 oxidoreductase on the aromatase activity of CYP19A1 polymorphisms R264C and R264H
S Parween, G DiNardo, F Baj, C Zhang… - The Journal of steroid …, 2020 - Elsevier
Abstract Aromatase (CYP19A1) converts androgens into estrogens and is required for
female sexual development and growth and development in both sexes. CYP19A1 is a …
female sexual development and growth and development in both sexes. CYP19A1 is a …
Novel CYP19A1 Mutations Extend the Genotype-Phenotype Correlation and Reveal the Impact on Ovarian Function
VP Praveen, A Ladjouze, KS Sauter… - Journal of the …, 2020 - academic.oup.com
Context The steroidogenic enzyme aromatase (CYP19A1) is required for estrogen
biosynthesis from androgen precursors in the ovary and extragonadal tissues. The role of …
biosynthesis from androgen precursors in the ovary and extragonadal tissues. The role of …
Mechanism of the dual activities of human CYP17A1 and binding to anti-prostate cancer drug abiraterone revealed by a novel V366M mutation causing 17, 20 lyase …
M Fernández-Cancio, N Camats, CE Flück, A Zalewski… - Pharmaceuticals, 2018 - mdpi.com
The CYP17A1 gene regulates sex steroid biosynthesis in humans through 17α-
hydroxylase/17, 20 lyase activities and is a target of anti-prostate cancer drug abiraterone. In …
hydroxylase/17, 20 lyase activities and is a target of anti-prostate cancer drug abiraterone. In …
Variability in human drug metabolizing cytochrome P450 CYP2C9, CYP2C19 and CYP3A5 activities caused by genetic variations in cytochrome P450 oxidoreductase
MNR Velazquez, S Parween, SS Udhane… - … and biophysical research …, 2019 - Elsevier
A broad spectrum of human diseases are caused by mutations in the NADPH cytochrome
P450 oxidoreductase (POR). Cytochrome P450 proteins perform several reactions …
P450 oxidoreductase (POR). Cytochrome P450 proteins perform several reactions …