Naturally available flavonoid aglycones as potential antiviral drug candidates against SARS-CoV-2
Flavonoids are important secondary plant metabolites that have been studied for a long time
for their therapeutic potential in inflammatory diseases because of their cytokine-modulatory …
for their therapeutic potential in inflammatory diseases because of their cytokine-modulatory …
A comprehensive update of various attempts by medicinal chemists to combat COVID-19 through natural products
The ongoing COVID-19 pandemic has resulted in a global panic because of its continual
evolution and recurring spikes. This serious malignancy is caused by the severe acute …
evolution and recurring spikes. This serious malignancy is caused by the severe acute …
Synthesis, X-ray diffraction analysis, quantum chemical studies and α-amylase inhibition of probenecid derived S-alkylphthalimide-oxadiazole-benzenesulfonamide …
Abstract Sulphonamide and 1, 3, 4-oxadiazole moieties are present as integral structural
parts of many drugs and pharmaceuticals. Taking into account the significance of these …
parts of many drugs and pharmaceuticals. Taking into account the significance of these …
[HTML][HTML] Design, synthesis, docking and mechanistic studies of new thiazolyl/thiazolidinylpyrimidine-2, 4-dione antiproliferative agents
In this article, we display on the synthesis and biological evaluation of a new series of
thiazolylpyrimidine 3a-l and thiazolidinylpyrimidine derivatives 5a-e. The structures of the …
thiazolylpyrimidine 3a-l and thiazolidinylpyrimidine derivatives 5a-e. The structures of the …
Deep-Sea Sponges and Corals off the Western Coast of Florida—Intracellular Mechanisms of Action of Bioactive Compounds and Technological Advances …
M Iskandar, KM Ruiz-Houston, SD Bracco, SR Sharkasi… - Marine Drugs, 2023 - mdpi.com
The majority of natural products utilized to treat a diverse array of human conditions and
diseases are derived from terrestrial sources. In recent years, marine ecosystems have …
diseases are derived from terrestrial sources. In recent years, marine ecosystems have …
Probing marine brown macroalgal phlorotannins as antiviral candidate against SARS-CoV-2: Molecular docking and dynamics simulation approach
S Gunaseelan, M Arunkumar, MK Aravind, S Gayathri… - Molecular Diversity, 2022 - Springer
Over the past year, owing to the emergent demand for the search for potential COVID-19
therapeutics, identifying alternative candidates from biological sources is one of the …
therapeutics, identifying alternative candidates from biological sources is one of the …
Phytochemical composition, in vitro antimicrobial, antioxidant, and enzyme inhibition activities, and in silico molecular docking and dynamics simulations of Centaurea …
Centaurea lycaonica is a local endemic species from the Centaurea L. genus. The
Centaurea species has a wide range of usage in treating diseases in folk medicine. There …
Centaurea species has a wide range of usage in treating diseases in folk medicine. There …
Molecular docking and dynamics simulation studies of ginsenosides with SARS-CoV-2 host and viral entry protein targets
P Shifeng, V Boopathi, M Murugesan… - Natural Product …, 2022 - journals.sagepub.com
Despite the contemporary advancements in the field of science and medicine, combating the
coronavirus disease 2019 (COVID-19) is extremely challenging in many aspects as the virus …
coronavirus disease 2019 (COVID-19) is extremely challenging in many aspects as the virus …
Potential drug candidates as P-glycoprotein inhibitors to reverse multidrug resistance in cancer: an in silico drug discovery study
MAA Ibrahim, KAA Abdeljawaad… - Journal of …, 2023 - Taylor & Francis
The failure of chemotherapy in the treatment of carcinoma is mainly due to the development
of multidrug resistance (MDR), which is largely caused by the overexpression of P …
of multidrug resistance (MDR), which is largely caused by the overexpression of P …
Exploring toxins for hunting SARS-CoV-2 main protease inhibitors: molecular docking, molecular dynamics, pharmacokinetic properties, and reactome study
MAA Ibrahim, AHM Abdelrahman, LA Jaragh-Alhadad… - Pharmaceuticals, 2022 - mdpi.com
The main protease (Mpro) is a potential druggable target in SARS-CoV-2 replication. Herein,
an in silico study was conducted to mine for Mpro inhibitors from toxin sources. A toxin and …
an in silico study was conducted to mine for Mpro inhibitors from toxin sources. A toxin and …