Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight

JK Kim, BT Tierney, EG Overbey, E Dantas… - Nature …, 2024 - nature.com
Spaceflight induces an immune response in astronauts. To better characterize this effect, we
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …

Application of radiation omics in the development of adverse outcome pathway networks: an example of radiation-induced cardiovascular disease

O Azimzadeh, S Moertl, R Ramadan… - … Journal of Radiation …, 2022 - Taylor & Francis
Background Epidemiological studies have indicated that exposure of the heart to doses of
ionizing radiation as low as 0.5 Gy increases the risk of cardiac morbidity and mortality with …

Cardiovascular Effects of Cosmic Radiation and Microgravity

O Giacinto, M Lusini, E Sammartini, A Minati… - Journal of Clinical …, 2024 - mdpi.com
Recent spaceflights involving nonprofessional people have opened the doors to the
suborbital space tourism business. However, they have also drawn public attention to the …

Spaceflight modulates the expression of key oxidative stress and cell cycle related genes in heart

A Kumar, CGT Tahimic, EAC Almeida… - International journal of …, 2021 - mdpi.com
Spaceflight causes cardiovascular changes due to microgravity-induced redistribution of
body fluids and musculoskeletal unloading. Cardiac deconditioning and atrophy on Earth …

Spaceflight-associated changes of snoRNAs in peripheral blood mononuclear cells and plasma exosomes—a pilot study

AK Rai, KS Rajan, M Bisserier… - Frontiers in …, 2022 - frontiersin.org
During spaceflight, astronauts are exposed to various physiological and psychological
stressors that have been associated with adverse health effects. Therefore, there is an …

Emerging role of exosomal long non-coding RNAs in spaceflight-associated risks in astronauts

M Bisserier, N Saffran, A Brojakowska… - Frontiers in …, 2022 - frontiersin.org
During spaceflight, astronauts are exposed to multiple unique environmental factors,
particularly microgravity and ionizing radiation, that can cause a range of harmful health …

Candidate biomarkers and persistent transcriptional responses after low and high dose ionizing radiation at high dose rate

Z Liu, J Cologne, SA Amundson… - International Journal of …, 2023 - Taylor & Francis
Purpose Development of an integrated time and dose model to explore the dynamics of
gene expression alterations and identify biomarkers for biodosimetry following low-and high …

[HTML][HTML] Lifetime evaluation of left ventricular structure and function in male C57BL/6J mice after gamma and space-type radiation exposure

A Brojakowska, CJ Jackson, M Bisserier… - International journal of …, 2023 - mdpi.com
The lifetime effects of space irradiation (IR) on left ventricular (LV) function are unknown. The
cardiac effects induced by space-type IR, specifically 5-ion simplified galactic cosmic ray …

[HTML][HTML] Space Travel: The Radiation and Microgravity Effects on the Cardiovascular System

AA Mircea, DV Pistritu, A Fortner, A Tanca… - International Journal of …, 2024 - mdpi.com
Space flight modulates the functions of the cardiovascular system. The exposure to space
conditions can alter the cerebral blood flow, as well as the venous return. Anemia, cardiac …

Impact on the Transcriptome of Proton Beam Irradiation Targeted at Healthy Cardiac Tissue of Mice

C Sala, M Tarozzi, G Simonetti, M Pazzaglia… - Cancers, 2024 - mdpi.com
Simple Summary The nature of different types of ionizing radiation is central to the modality
of affecting biological targets. The main data library on radiotherapy effects we can access is …