Natural compounds against nonalcoholic fatty liver disease: A review on the involvement of the LKB1/AMPK signaling pathway

N Omidkhoda, S Mahdiani, AW Hayes… - Phytotherapy …, 2023 - Wiley Online Library
Although various therapeutic approaches are used to manage nonalcoholic fatty liver
disease (NAFLD), the best approach to NAFLD management is unclear. NAFLD is a liver …

Nrf2-mediated therapeutic effects of dietary flavones in different diseases

W Huang, Y Zhong, B Gao, B Zheng… - Frontiers in Pharmacology, 2023 - frontiersin.org
Oxidative stress (OS) is a pathological status that occurs when the body's balance between
oxidants and antioxidant defense systems is broken, which can promote the development of …

[HTML][HTML] Interaction of luteolin, naringenin, and their sulfate and glucuronide conjugates with human serum albumin, cytochrome P450 (CYP2C9, CYP2C19, and …

H Kaci, S Bodnárová, E Fliszár-Nyúl, B Lemli… - Biomedicine & …, 2023 - Elsevier
Luteolin and naringenin are flavonoids found in various foods/beverages and present in
certain dietary supplements. After a high intake of these flavonoids, their sulfate and …

Luteolin and Vernodalol as Bioactive Compounds of Leaf and Root Vernonia amygdalina Extracts: Effects on α-Glucosidase, Glycation, ROS, Cell Viability, and In …

FM Djeujo, V Stablum, E Pangrazzi, E Ragazzi… - Pharmaceutics, 2023 - mdpi.com
The aqueous decoctions of Vernonia amygdalina (VA) leaves and roots are widely used in
traditional African medicine as an antidiabetic remedy. The amount of luteolin and …

A review of mechanisms underlying the protective effects of natural compounds against arsenic-induced neurotoxicity

N Najafi, R Rezaee, AW Hayes, G Karimi - Biometals, 2023 - Springer
Arsenic (As) is a toxic metalloid that is widely distributed in the earth's crust. People are
continuously exposed to this toxicant in their food and drinking water. Inorganic arsenic …

Drug discovery inspired by bioactive small molecules from nature

S Kim, SW Lim, J Choi - Animal Cells and Systems, 2022 - Taylor & Francis
Natural products (NPs) have greatly contributed to the development of novel treatments for
human diseases such as cancer, metabolic disorders, and infections. Compared to synthetic …

The roles and regulatory mechanisms of cigarette smoke constituents in vascular remodeling

S Zhou, J Du, W Li, Q Liu, Q Zhang, G Su… - International …, 2024 - Elsevier
Vascular remodeling is a dynamic process involving cellular and molecular changes,
including cell proliferation, migration, apoptosis and extracellular matrix (ECM) synthesis or …

Luteolin: A Promising Modulator of Apoptosis and Survival Signaling in Liver Cancer

P Rath, A Chauhan, A Ranjan, D Aggarwal… - … -Research and Practice, 2024 - Elsevier
Due to the increasing incidence of cancer and the difficulties in determining the safety profile
of existing therapeutic approaches, cancer research has recently become heavily involved …

Anti-Tumor Effects and Toxicity Reduction Mechanisms of Prunella vulgaris: A Comprehensive Review

N Ning, Y Nan, G Chen, S Huang, D Lu, Y Yang… - Molecules, 2024 - mdpi.com
Purpose: To investigate and systematically describe the mechanism of action of Prunella
vulgaris (P. vulgaris) against digestive system tumors and related toxicity reduction …

Fabrication of the Rapid Self-Assembly Hydrogels Loaded with Luteolin: Their Structural Characteristics and Protection Effect on Ulcerative Colitis

X Bi, H Peng, H Xiong, L Xiao, H Zhang, J Li, Y Sun - Foods, 2024 - mdpi.com
Luteolin (LUT) is a fat-soluble flavonoid known for its strong antioxidant and anti-
inflammatory properties. Nonetheless, its use in the food industry has been limited due to its …