Accumulating evidence suggests that oxidant stress alters many functions of the
endothelium, including modulation of vasomotor tone. Inactivation of nitric oxide (NO·) by …

Reactive oxygen species (ROS) are generated as by-products of cellular metabolism,
primarily in the mitochondria. When cellular production of ROS overwhelms its antioxidant …

This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

Reactive oxygen species have emerged as important molecules in cardiovascular function.
Recent work has shown that NAD (P) H oxidases are major sources of superoxide in …

The O2 J generated by this enzyme serves as the starting material for the production of a
vast assortment of reactive oxidants, including oxidized halogens, free radicals, and singlet …

Tetrahydrobiopterin is a critical cofactor for the NO synthases, and in its absence these
enzymes become “uncoupled,” producing reactive oxygen species (ROSs) rather than NO …

We have investigated the regulation of protein tyrosine phosphatases (PTPs) by reactive
oxygen species (ROS) in a cellular environment. We demonstrate that multiple PTPs were …

The importance of reactive oxygen species (ROS) in vascular physiology and pathology is
becoming increasingly evident. All cell types in the vascular wall produce ROS derived from …

Emerging evidence indicates that reactive oxygen species, especially superoxide and
hydrogen peroxide, are important signaling molecules in cardiovascular cells. Their …

Reactive oxygen species (ROS), including superoxide (· O 2−), hydrogen peroxide (H 2 O 2),
and hydroxyl anion (OH-), and reactive nitrogen species, such as nitric oxide (NO) and …