Population-based clinic-pathological studies have established that the most common
pathological substrate of dementia in community-dwelling elderly people is mixed …

Clinical studies have indicated that diabetes is associated with Alzheimer's disease (AD)
and neurodegeneration. However, the mechanisms underlying this association have not …

Alzheimer's disease (AD), the most common cause of dementia, is a complex and
multifactorial disease involving genetic and environmental factors, with …

Obesity is recognized as a significant risk factor for Alzheimer's disease (AD). Studies have
supported that obesity accelerates AD-related pathophysiology and memory impairment in …

Background As the prevalence of neurodegenerative diseases increases steadily, the need
to develop new treatment approaches intensifies and the possibility of targeting risk and …

The toxic conformer of amyloid β-protein (Aβ) ending at 42 (Aβ42), which contains a unique
turn conformation at amino acid residue positions 22 and 23 and tends to form oligomers …

Cholesterol and its oxidative derivative 27-hydroxycholesterol (27-OHC), synthesized by
CYP27A1, play an important role in Alzheimer's disease (AD) and phosphorylation of tau …

The term Western diet (WD) describes the consumption of large amounts of highly
processed foods, rich in simple sugars and saturated fats. Long-term WD feeding leads to …

Background Alzheimer's disease (AD) is the most common neurodegenerative disease and
type 2 diabetes (T2D) plays an important role in conferring the risk for AD. Although AD and …

Since the metabolic disorder may be the high risk that contribute to the progress of
Alzheimer's disease (AD). Overtaken of High-fat, high-glucose or high-cholesterol diet may …