▪ Abstract In the mid to late 1980s, studies were published that provided the first evidence for
the existence of glutamate receptors that are not ligand-gated cation channels but are …

Rationale l-Glutamate is the major excitatory neurotransmitter in the central nervous system
(CNS) and mediates its actions via activation of both ionotropic and metabotropic receptor …

The spatial–temporal characteristics of intracellular calcium ([Ca2+] i) changes elicited in
neurons and astrocytes by various types of stimuli were investigated by means of confocal …

Metabotropic (G-protein-coupled) glutamate (mGlu) receptors have now emerged as a
recognized, but still relatively new area of excitatory amino acid research. Current …

Two distinct forms of long-term depression (LTD), one dependent on the activation of NMDA
receptors (NMDARs) and the other dependent on the activation of metabotropic glutamate …

The first catalytic hydrocarboxylation of enamides and imines with CO2 to generate valuable
α, α‐disubstituted α‐amino acids is reported. Notably, excellent chemo‐and regio‐selectivity …

(S)-Glutamic acid (Glu), which is the main excitatory neurotransmitter in the central nervous
system (CNS), and other excitatory amino acids (EAAs) operate through four different …

The in vitro pharmacology of a structurally novel compound, LY341495, was investigated at
human recombinant metabotropic glutamate (mGlu) receptor subtypes expressed in non …

Metabotropic glutamate (mGlu) receptors have been considered as potential targets for
neuroprotective drugs, but the lack of specific drugs has limited the development of …

Almost 25 years after the first report that glutamate can activate receptors coupled to
heterotrimeric G-proteins, tremendous progress has been made in the field of metabotropic …