The human immunodeficiency virus: infectivity and mechanisms of pathogenesis

AS Fauci - Science, 1988 - science.org
Infection with the human immunodeficiency virus (HIV) results in a profound
immunosuppression due predominantly to a selective depletion of helper/inducer T …

POPULATION BIOLOGY OF HIV-1 INFECTION: Viral and CD4+ T Cell Demographics and Dynamics in Lymphatic Tissues

AT Haase - Annual review of immunology, 1999 - annualreviews.org
▪ Abstract Human immunodeficiency virus-1 (HIV-1) is usually transmitted through sexual
contact and in the very early stages of infection establishes a persistent infection in …

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

RB Jones, LC Ndhlovu, JD Barbour, PM Sheth… - The Journal of …, 2008 - rupress.org
Progressive loss of T cell functionality is a hallmark of chronic infection with human
immunodeficiency virus 1 (HIV-1). We have identified a novel population of dysfunctional T …

Positive Effects of Combined Antiretroviral Therapy on CD4+ T Cell Homeostasis and Function in Advanced HIV Disease

B Autran, G Carcelain, TS Li, C Blanc, D Mathez… - Science, 1997 - science.org
Highly active antiretroviral therapy (HAART) increases CD4+ cell numbers, but its ability to
correct the human immunodeficiency virus (HIV)–induced immune deficiency remains …

Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or …

JV Giorgi, LE Hultin, JA McKeating… - The Journal of …, 1999 - academic.oup.com
To define predictors of survival time in late human immunodeficiency virus type 1 (HIV-1)
disease, long-and short-duration survivors were studied after their CD4+ T cells fell to⩽ …

The AIDS dementia complex: I. Clinical features

BA Navia, BD Jordan, RW Price - Annals of Neurology: Official …, 1986 - Wiley Online Library
Of 70 autopsied patients with the acquired immune deficiency syndrome (AIDS), 46 suffered
progressive dementia that was frequently accompanied by motor and behavioral …

Vigorous HIV-1-Specific CD4+ T Cell Responses Associated with Control of Viremia

ES Rosenberg, JM Billingsley, AM Caliendo… - Science, 1997 - science.org
Virus-specific CD4+ T helper lymphocytes are critical to the maintenance of effective
immunity in a number of chronic viral infections, but are characteristically undetectable in …

High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR

M Piatak Jr, MS Saag, LC Yang, SJ Clark, JC Kappes… - Science, 1993 - science.org
Quantitative competitive polymerase chain reaction (QC-PCR) methods were used to
quantify virion-associated human immunodeficiency virus type-1 (HIV-1) RNA in plasma …

Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding

M Thali, JP Moore, C Furman, M Charles… - Journal of …, 1993 - Am Soc Microbiol
Interaction with the CD4 receptor enhances the exposure on the human immunodeficiency
type 1 gp120 exterior envelope glycoprotein of conserved, conformation-dependent …

The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1

JL Fahey, JMG Taylor, R Detels… - … England Journal of …, 1990 - Mass Medical Soc
We evaluated three cellular and five serologic markers that are affected by infection with the
human immunodeficiency virus type 1 (HIV-1) for their ability to predict the progression to …