Betulin and betulinic acid: Triterpenoids derivatives with a powerful biological potential

A Hordyjewska, A Ostapiuk, A Horecka… - Phytochemistry …, 2019 - Springer
Betulin, a pentacyclic triterpene and a plant pentacyclic triterpene metabolite, can be found
in large quantities in the outer bark of the birches (Betula, Betulaceae). Betulinic acid …

Betulin and its derivatives as novel compounds with different pharmacological effects

S Amiri, S Dastghaib, M Ahmadi, P Mehrbod… - Biotechnology …, 2020 - Elsevier
Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids
which possess a wide range of pharmacological activities. Recent evidence indicates that B …

A review on preparation of betulinic acid and its biological activities

H Lou, H Li, S Zhang, H Lu, Q Chen - Molecules, 2021 - mdpi.com
Betulinic acid, a pentacyclic triterpene, is distributed in a variety of plants, such as birch,
eucalyptus and plane trees. It shows a wide spectrum of biological and pharmacological …

Inhibitory effects of triterpenoid betulin on inflammatory mediators inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha, interleukin-6, and …

J Yu, M Li, D Zhan, C Shi, L Fang, C Ban… - Pharmacognosy …, 2020 - phcog.com
Background: Colon carcinogenesis is the third most commonly occurring malignant
neoplasm and the second most common cause of cancer-related deaths globally. Betulin …

Pharmacological activities of natural triterpenoids and their therapeutic implications

P Dzubak, M Hajduch, D Vydra, A Hustova… - Natural product …, 2006 - pubs.rsc.org
Covering: 1990–2005. Previous review: Nat. Prod. Rep., 2005, 22, 487 This article reviews
the pharmacological activity of naturally occurring triterpenoids excluding the degraded …

Pharmacological properties of the ubiquitous natural product betulin

S Alakurtti, T Mäkelä, S Koskimies… - European journal of …, 2006 - Elsevier
Betulin (lup-20 (29)-ene-3β, 28-diol) is an abundant naturally occurring triterpene and it is
found predominantly in bushes and trees forming the principal extractive (up to 30% of dry …

New pharmacological opportunities for betulinic acid

JL Ríos, S Máñez - Planta medica, 2018 - thieme-connect.com
Betulinic acid is a naturally occurring pentacyclic lupane-type triterpenoid usually isolated
from birch trees, but present in many other botanical sources. It is found in different plant …

[HTML][HTML] Potential antimalarials from Nigerian plants: a review

JO Adebayo, AU Krettli - Journal of ethnopharmacology, 2011 - Elsevier
Malaria, caused by parasites of the genus Plasmodium, is one of the leading infectious
diseases in many tropical regions, including Nigeria, a West African country where …

Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection

RH Cichewicz, SA Kouzi - Medicinal research reviews, 2004 - Wiley Online Library
Abstract 3β‐Hydroxy‐lup‐20 (29)‐en‐28‐oic acid (betulinic acid) is a pentacyclic lupane‐
type triterpene that is widely distributed throughout the plant kingdom. A variety of biological …

[PDF][PDF] Biological activities of lupeol

MBC Gallo, MJ Sarachine - Int. J. Biomed. Pharm. Sci, 2009 - globalsciencebooks.info
This review covers mainly the past 25 years of research on the biological activities of lupeol,
a significant lupane-type triterpene represented in the plant, fungi and animal kingdoms …