Extracellular matrices and cancer-associated fibroblasts: targets for cancer diagnosis and therapy?

I Belhabib, S Zaghdoudi, C Lac, C Bousquet, C Jean - Cancers, 2021 - mdpi.com
Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …

The role of tumour–stromal interactions in modifying drug response: challenges and opportunities

DW McMillin, JM Negri, CS Mitsiades - Nature reviews Drug discovery, 2013 - nature.com
The role of stromal cells and the tumour microenvironment in general in modulating tumour
sensitivity is increasingly becoming a key consideration for the development of active …

[HTML][HTML] Chemoresistance of cancer cells: requirements of tumor microenvironment-mimicking in vitro models in anti-cancer drug development

Y Jo, N Choi, K Kim, HJ Koo, J Choi, HN Kim - Theranostics, 2018 - ncbi.nlm.nih.gov
For decades, scientists have been using two-dimensional cell culture platforms for high-
throughput drug screening of anticancer drugs. Growing evidence indicates that the results …

[HTML][HTML] In vitro cancer cell–ECM interactions inform in vivo cancer treatment

AW Holle, JL Young, JP Spatz - Advanced drug delivery reviews, 2016 - Elsevier
The general progression of cancer drug development involves in vitro testing followed by
safety and efficacy evaluation in clinical trials. Due to the expense of bringing candidate …

The tension mounts: mechanics meets morphogenesis and malignancy

MJ Paszek, VM Weaver - Journal of mammary gland biology and …, 2004 - Springer
The tissue microenvironment regulates mammary gland development and tissue
homeostasis through soluble, insoluble and cellular cues that operate within the three …

From transformation to metastasis: deconstructing the extracellular matrix in breast cancer

S Kaushik, MW Pickup, VM Weaver - Cancer and Metastasis Reviews, 2016 - Springer
The extracellular matrix (ECM) is a guiding force that regulates various developmental
stages of the breast. In addition to providing structural support for the cells, it mediates …

Prenatal bisphenol A exposure induces preneoplastic lesions in the mammary gland in Wistar rats

M Durando, L Kass, J Piva… - Environmental …, 2007 - ehp.niehs.nih.gov
Background Humans are routinely exposed to bisphenol A (BPA), an estrogenic compound
that leaches from dental materials, food and beverage containers, and other consumer …

Cancer and aging: a model for the cancer promoting effects of the aging stroma

A Krtolica, J Campisi - The international journal of biochemistry & cell …, 2002 - Elsevier
The incidence of cancer rises exponentially with age in humans and many other mammalian
species. Malignant tumors are caused by an accumulation of oncogenic mutations. In …

The macrophage growth factor CSF-1 in mammary gland development and tumor progression

EY Lin, V Gouon-Evans, AV Nguyen… - Journal of mammary gland …, 2002 - Springer
Abstract Colony stimulating factor 1 (CSF-1), a major regulator of the mononuclear
phagocytic lineage, is expressed in more than 70% of human breast cancers and its …

β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib

C Huang, CC Park, SG Hilsenbeck, R Ward… - Breast cancer …, 2011 - Springer
Introduction The overexpression of human epidermal growth factor receptor (HER)-2 in 20%
of human breast cancers and its association with aggressive growth has led to widespread …