Extracellular matrices and cancer-associated fibroblasts: targets for cancer diagnosis and therapy?
I Belhabib, S Zaghdoudi, C Lac, C Bousquet, C Jean - Cancers, 2021 - mdpi.com
Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …
The role of tumour–stromal interactions in modifying drug response: challenges and opportunities
DW McMillin, JM Negri, CS Mitsiades - Nature reviews Drug discovery, 2013 - nature.com
The role of stromal cells and the tumour microenvironment in general in modulating tumour
sensitivity is increasingly becoming a key consideration for the development of active …
sensitivity is increasingly becoming a key consideration for the development of active …
[HTML][HTML] Chemoresistance of cancer cells: requirements of tumor microenvironment-mimicking in vitro models in anti-cancer drug development
For decades, scientists have been using two-dimensional cell culture platforms for high-
throughput drug screening of anticancer drugs. Growing evidence indicates that the results …
throughput drug screening of anticancer drugs. Growing evidence indicates that the results …
[HTML][HTML] In vitro cancer cell–ECM interactions inform in vivo cancer treatment
The general progression of cancer drug development involves in vitro testing followed by
safety and efficacy evaluation in clinical trials. Due to the expense of bringing candidate …
safety and efficacy evaluation in clinical trials. Due to the expense of bringing candidate …
The tension mounts: mechanics meets morphogenesis and malignancy
MJ Paszek, VM Weaver - Journal of mammary gland biology and …, 2004 - Springer
The tissue microenvironment regulates mammary gland development and tissue
homeostasis through soluble, insoluble and cellular cues that operate within the three …
homeostasis through soluble, insoluble and cellular cues that operate within the three …
From transformation to metastasis: deconstructing the extracellular matrix in breast cancer
The extracellular matrix (ECM) is a guiding force that regulates various developmental
stages of the breast. In addition to providing structural support for the cells, it mediates …
stages of the breast. In addition to providing structural support for the cells, it mediates …
Prenatal bisphenol A exposure induces preneoplastic lesions in the mammary gland in Wistar rats
M Durando, L Kass, J Piva… - Environmental …, 2007 - ehp.niehs.nih.gov
Background Humans are routinely exposed to bisphenol A (BPA), an estrogenic compound
that leaches from dental materials, food and beverage containers, and other consumer …
that leaches from dental materials, food and beverage containers, and other consumer …
Cancer and aging: a model for the cancer promoting effects of the aging stroma
A Krtolica, J Campisi - The international journal of biochemistry & cell …, 2002 - Elsevier
The incidence of cancer rises exponentially with age in humans and many other mammalian
species. Malignant tumors are caused by an accumulation of oncogenic mutations. In …
species. Malignant tumors are caused by an accumulation of oncogenic mutations. In …
The macrophage growth factor CSF-1 in mammary gland development and tumor progression
EY Lin, V Gouon-Evans, AV Nguyen… - Journal of mammary gland …, 2002 - Springer
Abstract Colony stimulating factor 1 (CSF-1), a major regulator of the mononuclear
phagocytic lineage, is expressed in more than 70% of human breast cancers and its …
phagocytic lineage, is expressed in more than 70% of human breast cancers and its …
β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib
C Huang, CC Park, SG Hilsenbeck, R Ward… - Breast cancer …, 2011 - Springer
Introduction The overexpression of human epidermal growth factor receptor (HER)-2 in 20%
of human breast cancers and its association with aggressive growth has led to widespread …
of human breast cancers and its association with aggressive growth has led to widespread …