Leishmaniasis: current status of available drugs and new potential drug targets

N Singh, M Kumar, RK Singh - Asian Pacific journal of tropical medicine, 2012 - Elsevier
The control of Leishmania infection relies primarily on chemotherapy till date. Resistance to
pentavalent antimonials, which have been the recommended drugs to treat cutaneous and …

Natural product based leads to fight against leishmaniasis

N Singh, BB Mishra, S Bajpai, RK Singh… - Bioorganic & medicinal …, 2014 - Elsevier
The growing incidence of parasitic resistance against generic pentavalent antimonials,
specifically for visceral disease in Indian subcontinent, is a serious issue in Leishmania …

Antileishmanial drug discovery: Comprehensive review of the last 10 years

JN Sangshetti, FAK Khan, AA Kulkarni, R Arote… - Rsc Advances, 2015 - pubs.rsc.org
Leishmaniasis, a group of diseases caused by hemoflagellate obligate intracellular protozoa
(trypanosomatids) from the genus Leishmania, has not received the attention it deserves …

A Systematic Review (1990–2021) of Wild Animals Infected with Zoonotic Leishmania

I Azami-Conesa, MT Gómez-Muñoz, RA Martínez-Díaz - Microorganisms, 2021 - mdpi.com
Leishmaniasis are neglected diseases caused by several species of Leishmania that affect
humans and many domestic and wild animals with a worldwide distribution. The objectives …

[HTML][HTML] Phylogenetic relationships of Leishmania species based on trypanosomatid barcode (SSU rDNA) and gGAPDH genes: Taxonomic revision of Leishmania (L.) …

A Marcili, MA Sperança, AP da Costa… - Infection, Genetics and …, 2014 - Elsevier
Phylogenetic studies on trypanosomatid barcode using V7V8 SSU rRNA and gGAPDH gene
sequences have provided support for redefining some trypanosomatid species and …

Toward an Ecological Framework for Assessing Reservoirs of Vector-Borne Pathogens: Wildlife Reservoirs of Trypanosoma cruzi across the Southern United States

CL Hodo, SA Hamer - ILAR journal, 2017 - academic.oup.com
Wildlife species are critical for both feeding vectors and serving as reservoirs of zoonotic
vector-borne pathogens. Transmission pathways leading to disease in humans or other …

High Trypanosoma cruzi infection prevalence associated with minimal cardiac pathology among wild carnivores in central Texas

R Curtis-Robles, BC Lewis, SA Hamer - International Journal for …, 2016 - Elsevier
Infection with the zoonotic vector-borne protozoal parasite Trypanosoma cruzi causes
Chagas disease in humans and dogs throughout the Americas. Despite the recognized …

[HTML][HTML] Nationwide exposure of US working dogs to the Chagas disease parasite, Trypanosoma cruzi

AC Meyers, JC Purnell, MM Ellis… - The American journal …, 2020 - ncbi.nlm.nih.gov
Trypanosoma cruzi is a zoonotic protozoan parasite vectored by triatomine insects that are
endemic to the Americas, including the southern United States. Surveillance of domestic …

Animal models for exploring Chagas disease pathogenesis and supporting drug discovery

AA Khan, MC Taylor, A Fortes Francisco… - Clinical microbiology …, 2024 - journals.asm.org
Infections with the parasitic protozoan Trypanosoma cruzi cause Chagas disease, which
results in serious cardiac and/or digestive pathology in 30%–40% of individuals. However …

Visceral leishmaniasis in zoo and wildlife

TD Souza, AP Turchetti, RT Fujiwara, TA Paixão… - Veterinary …, 2014 - Elsevier
Visceral leishmaniasis (VL) is an emerging zoonosis caused by Leishmania (Leishmania)
infantum. Although the domestic dog is the main vertebrate host, many zoo and wild …