Mounting evidence suggests a link between metabolic syndrome (MetS) such as diabetes,
obesity, non-alcoholic fatty liver disease in the progression of Alzheimer's disease (AD) …

Glutamate receptors play a crucial role in the central nervous system and are implicated in
different brain disorders. They play a significant role in the pathogenesis of …

Preclinical evidence suggests that antidepressants (ADs) may differentially influence
mitochondrial energetics. This study was conducted to investigate the relationship between …

Huntington's disease (HD), a neurodegenerative disease, normally starts in the prime of
adult life, followed by a gradual occurrence of psychiatric disturbances, cognitive and motor …

Animal models are used to better understand the various mechanisms involved in the
pathogenesis of diseases and explore potential pathways that will aid in discovering …

Long term suppression of succinate dehydrogenase by selective inhibitor 3-nitropropionic
acid has been used in rodents to model Huntington's disease where mitochondrial …

Individuals with mitochondrial disease often present with psychopathological comorbidity,
and mitochondrial dysfunction has been proposed as the underlying pathobiology in various …

Neuropsychiatric disorders have complex pathophysiological constructs, requiring
translational models to improve our understanding thereof. Mitochondrial dysfunction …

Background Brain mitochondrial dysfunction is implicated in the pathophysiology of mood
disorders. Brain cytochrome‐c‐oxidase (COX) activity is associated with the mitochondrial …

Background Oxidative stress is related to the pathogenesis of mood disorders, and the level
of oxidative stress may differ between bipolar disorder (BD) and major depressive disorder …