SMGR: a joint statistical method for integrative analysis of single-cell multi-omics data
Unravelling the regulatory programs from single-cell multi-omics data has long been one of
the major challenges in genomics, especially in the current emerging single-cell field …
the major challenges in genomics, especially in the current emerging single-cell field …
Oncoinformatic screening of the gene clusters involved in the HER2-positive breast cancer formation along with the in silico pharmacodynamic profiling of selective …
The HER2-positive patients occupy~ 30% of the total breast cancer patients globally where
no prevalent drugs are available to mitigate the frequent metastasis clinically except …
no prevalent drugs are available to mitigate the frequent metastasis clinically except …
Cell type evolution reconstruction across species through cell phylogenies of single-cell RNA sequencing data
The origin and evolution of cell types has emerged as a key topic in evolutionary biology.
Driven by rapidly accumulating single-cell datasets, recent attempts to infer cell type …
Driven by rapidly accumulating single-cell datasets, recent attempts to infer cell type …
Molecular models of bidirectional promoter regulation
S Nemsick, AS Hansen - Current Opinion in Structural Biology, 2024 - Elsevier
Approximately 11% of human genes are transcribed by a bidirectional promoter (BDP),
defined as two genes with< 1 kb between their transcription start sites. Despite their …
defined as two genes with< 1 kb between their transcription start sites. Despite their …
Complex regulatory networks influence pluripotent cell state transitions in human iPSCs
TD Arthur, JP Nguyen, A D'Antonio-Chronowska… - Nature …, 2024 - nature.com
Stem cells exist in vitro in a spectrum of interconvertible pluripotent states. Analyzing
hundreds of hiPSCs derived from different individuals, we show the proportions of these …
hundreds of hiPSCs derived from different individuals, we show the proportions of these …
Cell‐type‐specific transcriptomics uncovers spatial regulatory networks in bioenergy sorghum stems
J Fu, B McKinley, B James, W Chrisler… - The Plant …, 2024 - Wiley Online Library
Bioenergy sorghum is a low‐input, drought‐resilient, deep‐rooting annual crop that has high
biomass yield potential enabling the sustainable production of biofuels, biopower, and …
biomass yield potential enabling the sustainable production of biofuels, biopower, and …
[HTML][HTML] Single-cell transcriptomics illuminates regulatory steps driving anterior-posterior patterning of Drosophila embryonic mesoderm
Single-cell technologies promise to uncover how transcriptional programs orchestrate
complex processes during embryogenesis. Here, we apply a combination of single-cell …
complex processes during embryogenesis. Here, we apply a combination of single-cell …
Exploring the role of transcriptional and post‐transcriptional processes in mRNA co‐expression
Ó García‐Blay, PGA Verhagen, B Martin… - …, 2023 - Wiley Online Library
Co‐expression of two or more genes at the single‐cell level is usually associated with
functional co‐regulation. While mRNA co‐expression—measured as the correlation in …
functional co‐regulation. While mRNA co‐expression—measured as the correlation in …
Aging disrupts gene expression timing during muscle regeneration
JV Kurland, AA Cutler, JT Stanley, N Dalla Betta… - Stem Cell Reports, 2023 - cell.com
Skeletal muscle function and regenerative capacity decline during aging, yet factors driving
these changes are incompletely understood. Muscle regeneration requires temporally …
these changes are incompletely understood. Muscle regeneration requires temporally …
A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2
A lingering question in developmental biology has centered on how transcription factors with
widespread distribution in vertebrate embryos can perform tissue-specific functions. Here …
widespread distribution in vertebrate embryos can perform tissue-specific functions. Here …