Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

The characterization and performance of stable amorphous solid dispersion systems were
evaluated in 40 research papers reporting active pharmaceutical ingredient (API) dissolution …

The importance of drug transporters as one of the determinants of pharmacokinetics has
become increasingly evident [1]. While much research has been conducted focusing the role …

COVID-19 is announced as a global pandemic in 2020. Its mortality and morbidity rate are
rapidly increasing, with limited medications. The emergent outbreak of COVID-19 prompted …

The most accessible points of call for most African populations with respect to primary health
care are traditional health systems that include spiritual, religious, and herbal medicine. This …

Bile is a complex mixture that includes bile salts, the membrane phospholipid
phosphatidylcholine (PC), cholesterol and various endobiotic and xenobiotic toxins, each of …

Intestinal metabolism can limit oral bioavailability of drugs and increase the risk of drug
interactions. It is therefore important to be able to predict and quantify it in drug discovery …

CYP3A is one of the most important drug-metabolizing enzymes, determining the first-pass
metabolism, oral bioavailability, and elimination of many drugs. It is also an important …

Antiviral drugs (AvDs) are the primary resource in the global battle against viruses, including
the recent fight against corona virus disease 2019 (COVID-19). Most AvDs require multiple …

Significant intra-and interindividual variability has been observed in response to use of
pharmacological agents in treatment of HIV infection. Treatment of HIV infection is limited by …