The role of itaconate in host defense and inflammation

CG Peace, LAJ O'Neill - The Journal of clinical investigation, 2022 - Am Soc Clin Investig
Macrophages exposed to inflammatory stimuli including LPS undergo metabolic
reprogramming to facilitate macrophage effector function. This metabolic reprogramming …

Two for the price of one: itaconate and its derivatives as an anti-infective and anti-inflammatory immunometabolite

AF McGettrick, LAJ O'Neill - Current opinion in immunology, 2023 - Elsevier
The metabolite itaconate (ITA) and its derivatives, both chemically synthesized and
endogenous, have emerged as immunoregulators, with roles in limiting inflammation but …

Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice

J Song, Y Zhang, RA Frieler, A Andren… - The Journal of …, 2024 - Am Soc Clin Investig
Itaconate has emerged as a critical immunoregulatory metabolite. Here, we examined the
therapeutic potential of itaconate in atherosclerosis. We found that both itaconate and the …

Dimethyl itaconate induces long-term innate immune responses and confers protection against infection

AV Ferreira, S Kostidis, LA Groh, VACM Koeken… - Cell Reports, 2023 - cell.com
Itaconate is an immunomodulatory metabolite produced by immune cells under microbial
stimulation and certain pro-inflammatory conditions and triggers antioxidant and anti …

Anti-inflammatory and anti-oxidative electrospun nanofiber membrane promotes diabetic wound healing via macrophage modulation

J He, S Zhou, J Wang, B Sun, D Ni, J Wu… - Journal of …, 2024 - Springer
Background In the inflammatory milieu of diabetic chronic wounds, macrophages undergo
substantial metabolic reprogramming and play a pivotal role in orchestrating immune …

[HTML][HTML] Targeted macrophage phagocytosis by Irg1/itaconate axis improves the prognosis of intracerebral hemorrhagic stroke and peritonitis

Z Luo, Z Sheng, L Hu, L Shi, Y Tian, X Zhao, W Yang… - …, 2024 - thelancet.com
Background Macrophages are innate immune cells whose phagocytosis function is critical to
the prognosis of stroke and peritonitis. cis-aconitic decarboxylase immune-responsive gene …

The evolutionary tug-of-war of macrophage metabolism during bacterial infection

L Almeida, A Dhillon-LaBrooy, T Sparwasser - Trends in Endocrinology & …, 2024 - cell.com
The function and phenotype of macrophages are intimately linked with pathogen detection.
On sensing pathogen-derived signals and molecules, macrophages undergo a carefully …

Macrophages inhibit Coxiella burnetii by the ACOD1‐itaconate pathway for containment of Q fever

L Kohl, MNAA Siddique, B Bodendorfer… - EMBO Molecular …, 2023 - embopress.org
Infection with the intracellular bacterium Coxiella (C.) burnetii can cause chronic Q fever with
severe complications and limited treatment options. Here, we identify the enzyme cis …

Anti-inflammatory metabolites in the pathogenesis of bacterial infection

A Urso, A Prince - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
Host and pathogen metabolism have a major impact on the outcome of infection. The
microenvironment consisting of immune and stromal cells drives bacterial proliferation and …

Bacterial Burden Declines But Neutrophil Infiltration and Ocular Tissue Damage Persist in Experimental Staphylococcus epidermidis Endophthalmitis

S Das, S Singh, A Kumar - Frontiers in Cellular and Infection …, 2021 - frontiersin.org
Coagulase-negative staphylococci (CoNS), including Staphylococcus (S) epidermidis, are
responsible for~ 70% of all post-surgical endophthalmitis, a potentially blinding eye …