NK cell-based immune checkpoint inhibition
Immunotherapy, with an increasing number of therapeutic dimensions, is becoming an
important mode of treatment for cancer patients. The inhibition of immune checkpoints …
important mode of treatment for cancer patients. The inhibition of immune checkpoints …
Killer Ig-like receptors (KIRs): their role in NK cell modulation and developments leading to their clinical exploitation
Natural killer (NK) cells contribute to the first line of defense against viruses and to the
control of tumor growth and metastasis spread. The discovery of HLA class I specific …
control of tumor growth and metastasis spread. The discovery of HLA class I specific …
Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization
Background Programmed death 1 (PD-1) is an immunologic checkpoint that limits immune
responses by delivering potent inhibitory signals to T cells on interaction with specific …
responses by delivering potent inhibitory signals to T cells on interaction with specific …
Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion
The increase of cell surface sialic acid is a characteristic shared by many tumor types. A
correlation between hypersialylation and immunoprotection has been observed, but few …
correlation between hypersialylation and immunoprotection has been observed, but few …
Interactions between Siglec-7/9 receptors and ligands influence NK cell–dependent tumor immunosurveillance
C Jandus, KF Boligan, O Chijioke, H Liu… - The Journal of …, 2014 - Am Soc Clin Investig
Alteration of the surface glycosylation pattern on malignant cells potentially affects tumor
immunity by directly influencing interactions with glycan-binding proteins (lectins) on the …
immunity by directly influencing interactions with glycan-binding proteins (lectins) on the …
Genetically encoded chemical crosslinking of carbohydrate
Protein–carbohydrate interactions play important roles in various biological processes, such
as organism development, cancer metastasis, pathogen infection and immune response, but …
as organism development, cancer metastasis, pathogen infection and immune response, but …
Siglecs and their roles in the immune system
Cell surfaces in the immune system are richly equipped with a complex mixture of glycans,
which can be recognized by diverse glycan-binding proteins. The Siglecs are a family of …
which can be recognized by diverse glycan-binding proteins. The Siglecs are a family of …
Sialic acid–binding immunoglobulin-like lectins (Siglecs) detect self-associated molecular patterns to regulate immune responses
The mammalian immune system evolved to tightly regulate the elimination of pathogenic
microbes and neoplastic transformed cells while tolerating our own healthy cells. Here, we …
microbes and neoplastic transformed cells while tolerating our own healthy cells. Here, we …
Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis
Natural killer cells can discriminate between normal cells and cells that do not express
adequate amounts of major histocompatibility complex (MHC) class I molecules. The …
adequate amounts of major histocompatibility complex (MHC) class I molecules. The …
Immune inhibitory receptors
JV Ravetch, LL Lanier - Science, 2000 - science.org
With the detailed description and analysis of several inhibitory receptor systems on lymphoid
and myeloid cells, a central paradigm has emerged in which the pairing of activation and …
and myeloid cells, a central paradigm has emerged in which the pairing of activation and …