Little is known about the pathophysiology of pelvic organ prolapse (POP). In 1996, Jackson
presented a hypothesis on pelvic floor connective tissue that tried to explain the …

Objective: Genital prolapse is frequent in postmenopausal women; it describes the loss of
support to the pelvic organs, resulting in a herniation of these into the vaginal channel. This …

OBJECTIVE: As pelvic organ prolapse progresses, the morphology of the vagina
dramatically changes. The objective of this study was to determine whether these changes …

Introduction and hypothesis The pathophysiology of pelvic organ prolapse (POP) is
incompletely understood. The purpose of this study is to describe the current knowledge …

Objective To compare tissue markers of collagen metabolism in the uterosacral ligaments
with those in vaginal tissue in women with uterine prolapse. Design Prospective …

Introduction and hypothesis Our aim is to characterize prolapsed and non-prolapsed vaginal
tissue, and thus offer a better understanding of the genital prolapse physiopathology and an …

Biochemical studies of the vagina and its supportive connective tissues have improved
understanding of the contribution of altered connective tissue to the pathogenesis of …

Further research is required to ascertain the role of connective tissue components, including
smooth muscle, in the support of pelvic organs. Knowledge of biomechanical properties of …

The objective of the study was to determine the relationship between midsagittal vaginal
wall geometric parameters and the degree of anterior vaginal prolapse. We have previously …

OBJECTIVE: To compare the expression of collagen type I and matrix metalloproteinase-1
(MMP-1) in uterosacral ligament biopsies from women with and without pelvic organ …