Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …

The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that
both unwinds duplex DNA and powers fork progression during DNA replication. Consistent …

The licensing of eukaryotic DNA replication origins, which ensures once-per-cell-cycle
replication, involves the loading of six related minichromosome maintenance proteins …

The initiation of DNA replication represents a committing step to cell proliferation.
Appropriate replication onset depends on multiprotein complexes that help properly …

Ring-shaped hexameric helicases are essential motor proteins that separate duplex nucleic
acid strands for DNA replication, recombination, and transcriptional regulation. Two …

DNA replication licensing is now understood to be the pathway that leads to the assembly of
double hexamers of minichromosome maintenance (Mcm2–7) at origin sites. Cell division …

Pathogenic mycobacteria use the ESX-1 secretion system to escape the macrophage
phagosome and survive infection. We demonstrated that the ESX-1 system is regulated by …

The minichromosome maintenance (MCM) helicase complex is essential for the initiation
and elongation of DNA replication in both the eukaryotic and archaeal domains. The …

Cell division is a tightly-regulated process that involves the contribution of a large number of
proteins. Before they are able to undergo mitosis, cells must first synthesize new DNA …

Abstract The CMG (Cdc45–MCM–GINS) complex is the eukaryotic replicative helicase, the
enzyme that unwinds double-stranded DNA at replication forks. All three components of the …