Therapeutic potential of oxadiazole or furadiazole containing compounds

A Siwach, PK Verma - BMC chemistry, 2020 - Springer
As we know that, Oxadiazole or furadi azole ring containing derivatives are an important
class of heterocyclic compounds. A heterocyclic five-membered ring that possesses two …

1, 3, 4-Oxadiazole containing compounds as therapeutic targets for cancer therapy

MJ Ahsan - Mini Reviews in Medicinal Chemistry, 2022 - ingentaconnect.com
Background: Cancer is the first or second leading cause of premature death in 134 of 183
countries in the world. 1, 3, 4-Oxadiazoles are five membered heterocyclic rings containing …

Synthesis, antibacterial activity and in silico study of new bis (1, 3, 4-oxadiazoles)

AM Abdelfattah, AEM Mekky… - Synthetic …, 2022 - Taylor & Francis
In the current study, new bis (2, 5-disubstituted 1, 3, 4-oxadiazoles) linked to aliphatic cores
were efficiently prepared. For this purpose, the appropriate bis (aldehydes) and …

Photocatalyzed redox-neutral decarboxylative alkylation of heteroaryl methanamines

P Niu, J Yang, Y Yuan, Y Zhang, C Zhou, X Bao… - Green …, 2021 - pubs.rsc.org
A redox-neutral decarboxylative coupling reaction of heteroaryl methylamines with NHPI
esters derived from aliphatic carboxylic acids has been developed. By employing a copper …

Tandem synthesis, cytotoxicity, and in silico study of new 1, 3, 4‐oxadiazoles as potential thymidylate synthase inhibitors

SMH Sanad, AEM Mekky, AAM Ahmed - Archiv der Pharmazie, 2022 - Wiley Online Library
A new series of pyrrole‐linked mono‐and bis (1, 3, 4‐oxadiazole) hybrids, attached to
various arene units, was prepared using a two‐step tandem protocol. Therefore, a …

A KHSO4 mediated facile synthesis of 2-amino-1, 3, 4-oxadiazole derivatives

B Long, B Tian, Q Tang, X Hu, L Han, Z Wang, C Wang… - Tetrahedron, 2021 - Elsevier
A novel, efficient and mild KHSO 4 mediated synthesis for 2-amino-1, 3, 4-oxadiazoles has
been established via the cyclodesulfurization of benzoylhydrazine and isothiocyanate …

[HTML][HTML] Synthesis of designed new 1, 3, 4-oxadiazole functionalized pyrano [2, 3-f] chromene derivatives and their antimicrobial activities

K Alatawi, AF Qarah, H Alharbi, A Alisaac… - Heliyon, 2024 - cell.com
Abstract Diethyl 2-(((4-methyl-2-oxo-2H-chromen-7-yl) oxy) methylene) malonate (2) was
synthesized from coumarin 1 and diethyl ethoxymethylene malonate in ethanol, followed by …

Synthesis, characterisation and evaluation of oxadiazole as promising anticancer agent

SV Mamatha, SL Belagali, M Bhat - SN Applied Sciences, 2020 - Springer
A unique series oxadiazoles were synthesized by cyclization of benzophenone hydrazide,
followed by the nucleophillic alkylation of heterocyclic scaffold. Synthesized title compounds …

[HTML][HTML] Asymmetric synthesis of chiral heterobenzylic amines via visible-light-induced enantioselective C (sp3)-H alkylation

Y Huo, B Chen, X Ren, C Wang, R Qi, Z Xu - Green Synthesis and …, 2023 - Elsevier
The chiral heterobenzylic amines, such as α-alkyl substituted chiral oxadiazole methylamine
skeletons are widely present in pesticides and pharmaceuticals, due to their unique …

Chemical Modification of Curcumin into Its Semi-Synthetic Analogs Bearing Pyrimidinone Moiety as Anticancer Agents

O Afzal, M Yusuf, MJ Ahsan, ASA Altamimi, MA Bakht… - Plants, 2022 - mdpi.com
Natural products (NPs) continue to provide a structural template for the design of novel
therapeutic agents and expedite the drug discovery process. The majority of FDA-approved …