Infections by opportunistic pathogenic fungi, especially Candida species, Cryptococcus
neoformans, and Aspergillus fumigatus, are a serious medical problem in …

Much progress has been made in the last decade in identifying genes responsible for
antifungal resistance in Candida albicans. Attention has focused on five major C. albicans …

Rim protein (RmP) is an ABC transporter of unknown function in rod outer segment discs.
The human gene for RmP (ABCR) is affected in several recessive retinal degenerations …

Many bacterial pathogens achieve resistance to defensin-like cationic antimicrobial peptides
(CAMPs) by the multiple peptide resistance factor (MprF) protein. MprF plays a crucial role in …

Increasingly frequent reports have described the in vivo loss of daptomycin susceptibility in
association with clinical treatment failures. The mechanism (s) of daptomycin resistance is …

Infections by the opportunistic fungal pathogen Candida albicans are widely treated with the
antifungal agent fluconazole that inhibits the biosynthesis of ergosterol, the major sterol in …

Saccharomyces cerevisiae was the first eukaryotic organism whose complete genome
sequence has been determined, uncovering the existence of numerous genes encoding …

Overexpression of the ATP-binding cassette (ABC) drug transporter P-glycoprotein (P-gp) is
often responsible for the failure of chemotherapy as a treatment for human tumors. The …

Antifungal agents have greatly contributed to the improvement of public health.
Nevertheless, antifungal resistant pathogens have increased during the past decade …

The opportunistic human pathogens Candida albicans and other non-albicans species have
acquired considerable significance in the recent past due to the enhanced susceptibility of …