Calcitriol-loaded multifunctional nanospheres with superlubricity for advanced osteoarthritis treatment
Osteoarthritis (OA) is characterized by the lubrication dysfunction of a cartilage sliding
interface caused by chronic joint inflammation, and effective nonsurgical therapy for …
interface caused by chronic joint inflammation, and effective nonsurgical therapy for …
Axial compressive loading attenuates early osteoarthritis by reducing subchondral bone remodeling
Background: Mechanical loading and alendronate (ALN) can be used as noninvasive
physical therapy methods for osteoarthritis (OA). However, the timing and efficacy for …
physical therapy methods for osteoarthritis (OA). However, the timing and efficacy for …
Supramolecular 3 in 1: A Lubrication and Co-Delivery System for Synergistic Advanced Osteoarthritis Therapy
MM Chen, Y Li, Y Zhu, WC Geng, FY Chen, JJ Li… - ACS …, 2024 - ACS Publications
The complexity, heterogeneity, and drug resistance of diseases necessitate a shift in
therapeutic paradigms from monotherapy to combination therapy, which could augment …
therapeutic paradigms from monotherapy to combination therapy, which could augment …
[HTML][HTML] Temporal progression of subchondral bone alterations in OA models involving induction of compromised meniscus integrity in mice and rats: a scoping review
Objective To categorize the temporal progression of subchondral bone alterations induced
by compromising meniscus integrity in mouse and rat models of knee osteoarthritis (OA) …
by compromising meniscus integrity in mouse and rat models of knee osteoarthritis (OA) …
On-demand release of a selective MMP-13 blocker from an enzyme-responsive injectable hydrogel protects cartilage from degenerative progression in osteoarthritis
In osteoarthritis (OA), the degradation of cartilage is primarily driven by matrix
metalloprotease-13 (MMP-13). Hence, the inhibition of MMP-13 has emerged as an …
metalloprotease-13 (MMP-13). Hence, the inhibition of MMP-13 has emerged as an …
[HTML][HTML] Mechanotransduction in subchondral bone microenvironment and targeted interventions for osteoarthritis
R Feng, W Hu, Y Li, X Yao, J Li, X Li, J Zhang… - Mechanobiology in …, 2024 - Elsevier
Osteoarthritis (OA) is a progressive degenerative joint sickness related with mechanics,
obesity, ageing, etc., mainly characterized by cartilage degeneration, subchondral bone …
obesity, ageing, etc., mainly characterized by cartilage degeneration, subchondral bone …
[HTML][HTML] Senomorphic agent pterostilbene ameliorates osteoarthritis through the PI3K/AKT/NF-κB axis: An in vitro and in vivo study
Y Wang, H Zhao, S Jia, Q Wang, W Yao… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Objectives: Osteoarthritis (OA) is the most common joint disease in the world. Among the
many risk factors for OA, aging is one of the most critical factors. The treatment with senop …
many risk factors for OA, aging is one of the most critical factors. The treatment with senop …
[HTML][HTML] Joint instability causes catabolic enzyme production in chondrocytes prior to synovial cells in novel non-invasive ACL ruptured mouse model
K Takahata, K Arakawa, S Enomoto, Y Usami… - Osteoarthritis and …, 2023 - Elsevier
Summary Objective The Anterior Cruciate Ligament (ACL)-deficient model helps to clarify
the mechanism of knee osteoarthritis (OA); however, the conventional ACL injury model …
the mechanism of knee osteoarthritis (OA); however, the conventional ACL injury model …
Functional loss of terminal complement complex protects rabbits from injury-induced osteoarthritis on structural and cellular level
J Riegger, H Joos, V Möhler, F Leucht, K Rading… - Biomolecules, 2023 - mdpi.com
The terminal complement complex (TCC) has been described as a potential driver in the
pathogenesis of posttraumatic osteoarthritis (PTOA). However, sublytic TCC deposition …
pathogenesis of posttraumatic osteoarthritis (PTOA). However, sublytic TCC deposition …
[HTML][HTML] Bilateral changes in knee joint laxity during the first year after non-surgically treated anterior cruciate ligament injury
S Sonesson, J Kvist - Physical Therapy in Sport, 2022 - Elsevier
Objectives Analyse changes in knee laxity between 3, 6, 12 and 24 months after non-
surgically treated ACL injury and to analyse associations between knee laxity and knee …
surgically treated ACL injury and to analyse associations between knee laxity and knee …