Circadian rhythms occur in almost all species and control vital aspects of our physiology,
from sleeping and waking to neurotransmitter secretion and cellular metabolism …

Most organisms display endogenously produced∼ 24-hour fluctuations in physiology and
behavior, termed circadian rhythms. Circadian rhythms are driven by a transcriptional …

THE PAST decade has witnessed an upsurge in our understanding of the hypothalamic
regulation of appetite. Expression of appetite or the motivational drive toward an energy …

The discovery of leptin has enhanced understanding of the interrelationship between
adipose energy stores and neuronal circuits in the brain involved in energy balance and …

Most aspects of energy metabolism display clear variations during day and night. This daily
rhythmicity of metabolic functions, including hormone release, is governed by a circadian …

Leptin, the long-sought satiety factor of adipocytes origin, has emerged as one of the major
signals that relay the status of fat stores to the hypothalamus and plays a significant role in …

Nesfatin-1, derived from nucleobindin2, is expressed in the hypothalamus and reported in
one study to reduce food intake (FI) in rats. To characterize the central anorexigenic action of …

Energy homeostasis is controlled by a complex neuroendocrine system consisting of
peripheral signals like leptin and central signals, in particular, neuropeptides. Several …

At present it is not clear which factors are responsible for the diurnal pattern of plasma leptin
levels, although the timing of food intake and circulating hormones such as glucocorticoids …

To determine the relationships among plasma ghrelin and leptin concentrations and
hypothalamic ghrelin contents, and sleep, cortical brain temperature (Tcrt), and feeding, we …