[HTML][HTML] What is a cell type and how to define it?
H Zeng - Cell, 2022 - cell.com
Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …
phenotypic properties at multiple levels, making them challenging to define, categorize, and …
Insights into Alzheimer's disease from single-cell genomic approaches
MH Murdock, LH Tsai - Nature neuroscience, 2023 - nature.com
Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …
[HTML][HTML] A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …
types with specific spatial distribution patterns and structural and functional properties …
Benchmarking spatial and single-cell transcriptomics integration methods for transcript distribution prediction and cell type deconvolution
Spatial transcriptomics approaches have substantially advanced our capacity to detect the
spatial distribution of RNA transcripts in tissues, yet it remains challenging to characterize …
spatial distribution of RNA transcripts in tissues, yet it remains challenging to characterize …
[HTML][HTML] SCENIC+: single-cell multiomic inference of enhancers and gene regulatory networks
C Bravo González-Blas, S De Winter, G Hulselmans… - Nature …, 2023 - nature.com
Joint profiling of chromatin accessibility and gene expression in individual cells provides an
opportunity to decipher enhancer-driven gene regulatory networks (GRNs). Here we present …
opportunity to decipher enhancer-driven gene regulatory networks (GRNs). Here we present …
Cell2location maps fine-grained cell types in spatial transcriptomics
Spatial transcriptomic technologies promise to resolve cellular wiring diagrams of tissues in
health and disease, but comprehensive mapping of cell types in situ remains a challenge …
health and disease, but comprehensive mapping of cell types in situ remains a challenge …
[HTML][HTML] Spatial epigenome–transcriptome co-profiling of mammalian tissues
Emerging spatial technologies, including spatial transcriptomics and spatial epigenomics,
are becoming powerful tools for profiling of cellular states in the tissue context,,,–. However …
are becoming powerful tools for profiling of cellular states in the tissue context,,,–. However …
[HTML][HTML] Comparative cellular analysis of motor cortex in human, marmoset and mouse
The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …
[HTML][HTML] Molecular and spatial signatures of mouse brain aging at single-cell resolution
The diversity and complex organization of cells in the brain have hindered systematic
characterization of age-related changes in its cellular and molecular architecture, limiting …
characterization of age-related changes in its cellular and molecular architecture, limiting …
Transcriptomic diversity of cell types across the adult human brain
The human brain directs complex behaviors, ranging from fine motor skills to abstract
intelligence, but the diversity of cell types that support these skills has not been fully …
intelligence, but the diversity of cell types that support these skills has not been fully …