[HTML][HTML] B vitamins and one-carbon metabolism: implications in human health and disease

P Lyon, V Strippoli, B Fang, L Cimmino - Nutrients, 2020 - mdpi.com
Vitamins B9 (folate) and B12 are essential water-soluble vitamins that play a crucial role in
the maintenance of one-carbon metabolism: a set of interconnected biochemical pathways …

Methylmalonic acid in aging and disease

J Tejero, F Lazure, AP Gomes - Trends in Endocrinology & Metabolism, 2024 - cell.com
Metabolic byproducts have conventionally been disregarded as waste products without
functions. In this opinion article, we bring to light the multifaceted role of methylmalonic acid …

[HTML][HTML] Mitochondrial disease, mitophagy, and cellular distress in methylmalonic acidemia

A Luciani, MCS Denley, LP Govers… - Cellular and Molecular …, 2021 - Springer
Mitochondria—the intracellular powerhouse in which nutrients are converted into energy in
the form of ATP or heat—are highly dynamic, double-membraned organelles that harness a …

Stable Co (II)-based coordination polymer as fluorescence sensor for the discriminative sensing of biomarker methylmalonic acid

R Luo, CG Xu, DM Zhang, LL Wang, RX Wu, GB Chen… - Talanta, 2023 - Elsevier
Three novel Co-based coordination polymers including {[Co (L)(μ 3-O) 1/3] 2} n (1),{[Co
(L)(bimb)]} n (2) and {[Co (L)(bimmb) 1/2]} n (3)(H 2 L= 2, 6-di (4-carboxylphenyl)-4-(4 …

[HTML][HTML] Dopamine‑iron homeostasis interaction rescues mitochondrial fitness in Parkinson's disease

C Buoso, M Seifert, M Lang, CM Griffith… - Neurobiology of …, 2024 - Elsevier
Imbalances of iron and dopamine metabolism along with mitochondrial dysfunction have
been linked to the pathogenesis of Parkinson's disease (PD). We have previously suggested …

Neurologic outcome following liver transplantation for methylmalonic aciduria

D Martinelli, G Catesini, B Greco… - Journal of Inherited …, 2023 - Wiley Online Library
Liver and liver/kidney transplantation are increasingly used in methylmalonic aciduria, but
little is known on their impact on CNS. The effect of transplantation on neurological outcome …

[HTML][HTML] Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency

P Forny, X Bonilla, D Lamparter, W Shao, T Plessl… - Nature …, 2023 - nature.com
Methylmalonic aciduria (MMA) is an inborn error of metabolism with multiple monogenic
causes and a poorly understood pathogenesis, leading to the absence of effective causal …

The efficacy of anti‐proteolytic peptide R7I in intestinal inflammation, function, microbiota, and metabolites by multi‐omics analysis in murine bacterial enteritis

T Sun, X Liu, Y Su, Z Wang, B Cheng… - Bioengineering & …, 2023 - Wiley Online Library
Increased antibiotic resistance poses a major limitation in tackling inflammatory bowel
disease and presents a large challenge for global health care. Antimicrobial peptides …

[HTML][HTML] Applications of Boolean modeling to study the dynamics of a complex disease and therapeutics responses

AA Hemedan, R Schneider… - Frontiers in bioinformatics, 2023 - frontiersin.org
Computational modeling has emerged as a critical tool in investigating the complex
molecular processes involved in biological systems and diseases. In this study, we apply …

An ultrastable zinc-based organic framework as a recyclable luminescent probe for methylmalonic acid detection

X Zhang, Y Tian, J Shi, X Kang, Z Liu - Journal of Materials Chemistry …, 2022 - pubs.rsc.org
Methylmalonic acid (MMA) as a functional marker of vitamin B12 deficiency has attracted
extensive attention. However, the highly selective and sensitive detection of MMA in a …