All viable bacterial cells, whether they divide symmetrically or asymmetrically, must
coordinate their growth, division, cell volume and shape with the inheritance of the genome …

During the cell division cycle of all bacteria, DNA-protein complexes termed orisomes trigger
the onset of chromosome duplication. Orisome assembly is both staged and stringently …

Initiation of DNA Replication is tightly regulated in all cells since imbalances in chromosomal
copy number are deleterious and often lethal. In bacteria such as Bacillus subtilis and …

The initiation of chromosomal DNA replication starts at a replication origin, which in bacteria
is a discrete locus that contains DNA sequence motifs recognized by an initiator protein …

In many bacteria the rate of DNA replication is linked with cellular physiology to ensure that
genome duplication is coordinated with growth. Nutrient-mediated growth rate control of …

DnaA is a conserved key regulator of replication initiation in bacteria, and is homologous to
ORC proteins in archaea and in eukaryotic cells. The ATPase binds to several high affinity …

Bacteria, like all cells, must precisely duplicate their genomes before they divide. Regulation
of this critical process focuses on forming a pre-replicative nucleoprotein complex, termed …

Chromosome copy number in cells is controlled so that the frequency of initiation of DNA
replication matches that of cell division. In bacteria, this is achieved through regulation of the …

The primary role of the bacterial protein DnaA is to initiate chromosomal replication. The
DnaA protein binds to DNA at the origin of chromosomal replication (oriC) and assembles …

In all cells, initiation of chromosome replication depends on the activity of AAA+ initiator
proteins that form complexes with replication origin DNA. In bacteria, the conserved …