Post-translational modification (PTM) in histone proteins is a covalent modification which
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …

Research over the past three decades has firmly established lysine acetyltransferases
(KATs) as central players in regulating transcription. Recent advances in genomic …

Protein aggregation is the hallmark of neurodegeneration, but the molecular mechanisms
underlying late-onset Alzheimer's disease (AD) are unclear. Here we integrated …

Atherosclerosis, which is the most common chronic disease of the coronary artery,
constitutes a vascular pathology induced by inflammation and plaque accumulation within …

Aging is characterized by functional decline of diverse organs and an increased risk for
several diseases. Therefore, a high interest exists in understanding the molecular …

Cytokine-induced beta cell dysfunction is a hallmark of type 2 diabetes (T2D). Chronic
exposure of beta cells to inflammatory cytokines affects gene expression and impairs insulin …

The activation of carboxylic acids to thioesters plays an important role in biology. However,
biochemical studies and biotechnological applications are hampered by a general lack of …

Evidence for research over the past decade shows that epigenetic regulation mechanisms
run through the development and prognosis of tumors. Therefore, small molecular …

Autophagy is a critical process to maintain homeostasis, differentiation, and development.
How autophagy is tightly regulated by nutritional changes is poorly understood. Here, we …

Background & Aims Owing to the lack of genetic animal models that adequately recreate key
clinical characteristics of cirrhosis, the molecular pathogenesis of cirrhosis has been poorly …