Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …

Hutchinson–Gilford progeria syndrome (HGPS or progeria) is typically caused by a
dominant-negative C• G-to-T• A mutation (c. 1824 C> T; p. G608G) in LMNA, the gene that …

Senescence compromises the essential role that the endothelium plays in maintaining
vascular homeostasis, so promoting endothelial dysfunction and the development of age …

Obesity is characterized by the excessive deposition of fat that may interfere with the normal
metabolic process of the body. It is a chronic condition associated with various metabolic …

Post-translational modifications (PTMs) have been proposed as a link between the oxidative
stress-inflammation-ageing trinity, thereby affecting several hallmarks of ageing …

The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM
versican binding molecules such as hyaluronan, tumor necrosis factor stimulated gene-6 …

Atherosclerosis is classed as a disease of aging, such that increasing age is an independent
risk factor for the development of atherosclerosis. Atherosclerosis is also associated with …

Ageing is the predominant risk factor for many common diseases. Human premature ageing
diseases are powerful model systems to identify and characterize cellular mechanisms that …

Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …