Emerging targets in photopharmacology
MM Lerch, MJ Hansen, GM van Dam… - Angewandte Chemie …, 2016 - Wiley Online Library
The field of photopharmacology uses molecular photoswitches to establish control over the
action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of …
action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of …
Descending control of pain
MJ Millan - Progress in neurobiology, 2002 - Elsevier
Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …
information from the viscera, skin and other organs is subject to extensive processing by a …
Structures of the entire human opioid receptor family
Opioids are effective analgesics, but their use is beset by serious side effects, including
addiction and respiratory depression, which contribute to the ongoing opioid crisis. The …
addiction and respiratory depression, which contribute to the ongoing opioid crisis. The …
Structure of the µ-opioid receptor–Gi protein complex
The μ-opioid receptor (μOR) is a G-protein-coupled receptor (GPCR) and the target of most
clinically and recreationally used opioids. The induced positive effects of analgesia and …
clinically and recreationally used opioids. The induced positive effects of analgesia and …
Structure of a signaling cannabinoid receptor 1-G protein complex
Cannabis elicits its mood-enhancing and analgesic effects through the cannabinoid receptor
1 (CB1), a G protein-coupled receptor (GPCR) that signals primarily through the adenylyl …
1 (CB1), a G protein-coupled receptor (GPCR) that signals primarily through the adenylyl …
Melanin pigmentation in mammalian skin and its hormonal regulation
A Slominski, DJ Tobin, S Shibahara… - Physiological …, 2004 - journals.physiology.org
Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social
communication, and protection against harmful effects of solar radiation. Melanogenesis is …
communication, and protection against harmful effects of solar radiation. Melanogenesis is …
Opioid receptors
M Waldhoer, SE Bartlett… - Annual review of …, 2004 - annualreviews.org
▪ Abstract Opioid receptors belong to the large superfamily of seven transmembrane-
spanning (7TM) G protein-coupled receptors (GPCRs). As a class, GPCRs are of …
spanning (7TM) G protein-coupled receptors (GPCRs). As a class, GPCRs are of …
Dopamine as a prolactin (PRL) inhibitor
N Ben-Jonathan, R Hnasko - Endocrine reviews, 2001 - academic.oup.com
Dopamine is a small and relatively simple molecule that fulfills diverse functions. Within the
brain, it acts as a classical neurotransmitter whose attenuation or overactivity can result in …
brain, it acts as a classical neurotransmitter whose attenuation or overactivity can result in …
Cellular and synaptic adaptations mediating opioid dependence
JT Williams, MDJ Christie… - Physiological …, 2001 - journals.physiology.org
Although opioids are highly effective for the treatment of pain, they are also known to be
intensely addictive. There has been a massive research investment in the development of …
intensely addictive. There has been a massive research investment in the development of …
[HTML][HTML] Crosstalk between Mu-Opioid receptors and neuroinflammation: Consequences for drug addiction and pain
J Cuitavi, JV Torres-Pérez, JD Lorente… - Neuroscience & …, 2023 - Elsevier
Abstract Mu-Opioid Receptors (MORs) are well-known for participating in analgesia,
sedation, drug addiction, and other physiological functions. Although MORs have been …
sedation, drug addiction, and other physiological functions. Although MORs have been …