Neuroinflammatory mechanisms in ischemic stroke: focus on cardioembolic stroke, background, and therapeutic approaches
One of the most important causes of neurological morbidity and mortality in the world is
ischemic stroke. It can be a result of multiple events such as embolism with a cardiac origin …
ischemic stroke. It can be a result of multiple events such as embolism with a cardiac origin …
The role of myelin and oligodendrocytes in axonal energy metabolism
Highlights•Myelin is an insulator that can shield long axons from rapid access to
metabolites.•Oligodendrocytes can 'feed'axons with glycolysis products such as …
metabolites.•Oligodendrocytes can 'feed'axons with glycolysis products such as …
The impact of cytokines in neuroinflammation-mediated stroke
S Kumari, R Dhapola, P Sharma, P Nagar… - Cytokine & Growth …, 2024 - Elsevier
Cerebral stroke is ranked as the third most common contributor to global mortality and
disability. The involvement of inflammatory mechanisms, both peripherally and within the …
disability. The involvement of inflammatory mechanisms, both peripherally and within the …
[HTML][HTML] Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease
The responses of central nervous system (CNS) cells such as neurons and glia in
neurodegenerative diseases (NDs) suggest that regulation of neuronal and glial functions …
neurodegenerative diseases (NDs) suggest that regulation of neuronal and glial functions …
Maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons
KA Lüders, S Nessler, K Kusch, J Patzig, RB Jung… - Glia, 2019 - Wiley Online Library
Proteolipid protein (PLP) is the most abundant integral membrane protein in central nervous
system (CNS) myelin. Expression of the Plp‐gene in oligodendrocytes is not essential for the …
system (CNS) myelin. Expression of the Plp‐gene in oligodendrocytes is not essential for the …
Molecular biology of atherosclerotic ischemic strokes
A Tuttolomondo, MG Puleo, MC Velardo… - International journal of …, 2020 - mdpi.com
Among the causes of global death and disability, ischemic stroke (also known as cerebral
ischemia) plays a pivotal role, by determining the highest number of worldwide mortality …
ischemia) plays a pivotal role, by determining the highest number of worldwide mortality …
[HTML][HTML] Role of neuroinflammation in ischemic stroke
R Liu, MX Pan, JC Tang, Y Zhang, HB Liao… - Neuroimmunology …, 2017 - oaepublish.com
Ischemic stroke causes the depletion of energy and induce excitotoxicity and
neuroinflammation in the brain that results from thrombotic blockage. Neuroinflammation …
neuroinflammation in the brain that results from thrombotic blockage. Neuroinflammation …
Immune cells perturb axons and impair neuronal survival in a mouse model of infantile neuronal ceroid lipofuscinosis
The neuronal ceroid lipofuscinoses are fatal neurodegenerative disorders in which the
visual system is affected early in disease progression. A typical accompanying feature is …
visual system is affected early in disease progression. A typical accompanying feature is …
Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2
Proteolipid protein (PLP) is the most abundant integral membrane protein in compact central
nervous system myelin, and null mutations of the PLP1 gene cause spastic paraplegia type …
nervous system myelin, and null mutations of the PLP1 gene cause spastic paraplegia type …
Axonal and neuronal degeneration in myelin diseases
N Ohno, K Ikenaka - Neuroscience Research, 2019 - Elsevier
Myelin is a multilamellar cell membrane around axons and is essential for fast saltatory
conduction and maintenance of axonal integrity and survival. Congenital and acquired …
conduction and maintenance of axonal integrity and survival. Congenital and acquired …