Genetic pain loss includes congenital insensitivity to pain (CIP), hereditary sensory
neuropathies and, if autonomic nerves are involved, hereditary sensory and autonomic …

Small‐fiber neuropathy (SFN) is a disorder of thinly myelinated Aδ and unmyelinated C
fibers. SFN is clinically dominated by neuropathic pain and autonomic complaints, leading to …

Introduction or background Congenital insensitivity to pain (CIP) is caused by extremely rare
Mendelian genetic disorders. CIP individuals demonstrate the unexpectedly severe …

Chronic pain is a global problem affecting up to 20% of the world's population and has a
significant economic, social and personal cost to society. Sensory neurons of the dorsal root …

Congenital insensitivity to pain (CIP) is an extremely rare phenotype characterized by the
inability to perceive pain (absence of nociception) from birth. Individuals with CIP do not feel …

Abstract Voltage-activated Na+(Na V) channels are crucial contributors to rapid electrical
signaling in the human body. As such, they are among the most targeted membrane proteins …

Voltage-gated sodium channel Nav1. 9 is a threshold channel that regulates action potential
firing. Nav1. 9 is preferentially expressed in myenteric neurons, and small-diameter dorsal …

Although necessary for human survival, pain may sometimes become pathologic if long-
lasting and associated with alterations in its signaling pathway. Opioid painkillers are …

The voltage-gated sodium channel NaV1. 8 is prominently expressed in the soma and
axons of small-caliber sensory neurons, and pathogenic variants of the corresponding gene …

Objective To test the hypothesis that many patients presenting with congenital insensitivity to
pain have lesser known or unidentified mutations not captured by conventional genetic …