Dysregulated pH is a common characteristic of cancer cells, as they have an increased
intracellular pH (pHi) and a decreased extracellular pH (pHe) compared with normal cells …

Abstract Since Otto Warburg reported the 'addiction'of cancer cells to fermentative glycolysis,
a metabolic pathway that provides energy and building blocks, thousands of studies have …

Solid tumors are generally characterized by an acidic tumor microenvironment (TME) that
favors cancer progression, therapy resistance and immune evasion. By single-cell RNA …

Alterations in tumour metabolism and acid/base regulation result in the formation of a hostile
environment, which fosters tumour growth and metastasis. Acid/base homoeostasis in …

Tumors often show, compared to normal tissues, a markedly decreased extracellular pH
resulting from anaerobic or aerobic glycolysis in combination with a reduced removal of …

Cancer cells are optimised for growth and survival via an ability to outcompete normal cells
in their microenvironment. Many of these advantageous cellular adaptations are promoted …

Carbonic anhydrase IX (CAIX) is a hypoxia inducible factor 1-induced, cell surface pH
regulating enzyme with an established role in tumor progression and clinical outcome …

The highly regulated pH of cells and the less-regulated pH of the surrounding extracellular
matrix (ECM) is the result of a delicate balance between metabolic processes and proton …

MicroRNAs (miRNAs) are known to affect the occurrence and progression of cancer. We
therefore evaluated the involvement of miR-223-3p in renal cell cancer. MiR-223-3p was …

Tumor hypoxia is associated clinically with therapeutic resistance and poor patient
outcomes. One feature of tumor hypoxia is activated expression of carbonic anhydrase IX …