Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for
restoring the epidermis after injury through a process termed epithelialization. This review …

The field of regenerative medicine holds considerable promise for treating diseases that are
currently intractable. Although many researchers are adopting the strategy of cell …

Previous studies have shown that mouse dermis is composed of functionally distinct
fibroblast lineages. To explore the extent of fibroblast heterogeneity in human skin, we used …

Curcumin is a compound isolated from turmeric, a plant known for its medicinal use.
Recently, there is a growing interest in the medical community in identifying novel, low-cost …

INTRODUCTION During aging, most organs in mammals become smaller (miniaturize) or
thinner, and their functions and regenerative capability also decline. Histologically, tissue …

Lineage tracing is the identification of all progeny of a single cell. Although its origins date
back to developmental biology of invertebrates in the 19 th century, lineage tracing is now …

Fibroblasts are found in most tissues, yet they remain poorly characterised. Different
fibroblast subpopulations with distinct functions have been identified in the skin. This …

Following a skin injury, the damaged tissue is repaired through the coordinated biological
actions that constitute the cutaneous healing response. In mammals, repaired skin is not …

Central to the classical hematopoietic stem cell (HSC) paradigm is the concept that the
maintenance of blood cell numbers is exclusively executed by a discrete physical entity: the …

Cell Science at a Glance 1179 interactions during development and in postnatal life
(Blanpain and Fuchs, 2009; Müller-Röver et al., 2001; Schmidt-Ullrich and Paus, 2005; Watt …