Bladder cancer is one of the most common malignancies in the world. Cisplatin is one of the
most potent and widely used anticancer drugs and has been employed in several …

The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological
functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is …

As a critical member of the ubiquitin-specific proteolytic enzyme family, ubiquitin-specific
peptidase 20 (USP20) regulates the stability of proteins via multiple signaling pathways. In …

Highlights•Drug resistance towards chemotherapy and molecularly targeted therapies
remains a great challenge in cancer treatments.•Deubiquitinating enzymes (DUBs) regulate …

Chemotherapy resistance is a major limiting factor for the extensive use of chemotherapeutic
drugs in cancer treatment. Despite the large number of newly discovered medications …

A substantial number of colon cancer patients do not benefit from immunotherapy using
programmed cell death 1 (PD1) antibodies. Therefore, combination therapy drugs are …

Abstract Objectives Targeting the deubiquitinases (DUBs) has become a promising avenue
for anti‐cancer drug development. However, the effect and mechanism of pan‐DUB …

Apoptosis, a form of programmed cell death, is a highly regulated process critical for tissue
development, homeostasis, and pathogenesis of various diseases. Hyperactive apoptosis …

Cisplatin-based chemotherapy is the standard treatment for bladder urothelial carcinoma
(UC). Most patients experience chemoresistance, the primary cause of treatment failure …

The balance between ubiquitination and deubiquitination is crucial for protein stability,
function and location under physiological conditions. Dysregulation of E1/E2/E3 ligases or …