Mutations and chromosomal translocations occur in leukemic cells that result in elevated
expression or constitutive activation of various growth factor receptors and downstream …

Human cells in culture have a limited proliferative capacity. After a period of vigorous
proliferation, the rate of cell division declines and a number of changes occur in the cells …

The induction of senescence-like growth arrest has emerged as a putative contributor to the
anticancer effects of chemotherapeutic agents. Clinical trials are underway to evaluate the …

The purpose of this investigation was to examine the activation (phosphorylation) and total
protein content of MAPK signalling cascade proteins (ERK 1/2, p90RSK, Mnk 1, eIF4E, p38 …

After a limited number of divisions, most eukaryotic cells grown in culture will undergo a
terminal growth arrest called cellular senescence. This growth arrest is thought to be a …

Malignant melanoma is an aggressive tumor of the skin with a poor prognosis for patients
with advanced disease. It is resistant to current therapeutic approaches. In melanoma, both …

Background: The phosphatidylinositol 3-kinase (PI3K)/phosphatase and tensin homolog
(PTEN)/v-akt murine thymoma viral oncogene homolog (Akt)/mammalian target of rapamycin …

The extracellular signal-regulated kinase 1 and 2 (ERK1/2) mitogen-activated protein (MAP)
kinase signaling pathway plays an important role in the proliferative response of mammalian …

Hyporesponsiveness to growth factors is one of the fundamental characteristics of senescent
cells. We previously reported that the up-regulation of caveolin attenuates the growth factor …

To evaluate the anti-inflammatory effect of β-glucans from Lentinus edodes, and its
molecular mechanism, the dextran sulfate sodium salt (DSS) induced colitis model of mice …