Cerebrovascular dysregulation is a hallmark of Alzheimer's disease (AD), but the changes
that occur in specific cell types have not been fully characterized. Here, we profile single …

Abstract The BMP/TGFβ-Smad, Notch and VEGF signaling guides formation of endothelial
tip and stalk cells. However, the crosstalk of bone morphogenetic proteins (BMPs) and …

How chromosomes are organized within the tridimensional space of the nucleus and how
can this organization affect genome function have been long-standing questions on the path …

The aryl hydrocarbon receptor (AHR) is a markedly established regulator of a plethora of
cellular and molecular processes. Its initial role in the detoxification of xenobiotic …

Genomic information is selectively used to direct spatial and temporal gene expression
during differentiation. Interactions between topologically associating domains (TADs) and …

A growing body of evidence supports the notion that variation in gene regulation plays a
crucial role in both speciation and adaptation. However, a comprehensive functional …

Super-enhancers are clusters of enhancers associated with cell lineage. They can be
powerful gene-regulators and may be useful in cell-type specific viral-vector development …

Objective: Previous studies have demonstrated that the expression of several lysine (K)-
specific demethylases (KDMs) is induced by hypoxia. Here, we sought to investigate the …

Background: The human genome folds in 3 dimensions to form thousands of chromatin
loops inside the nucleus, encasing genes and cis-regulatory elements for accurate gene …

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding
RNA overexpressed in various cancers that promotes cell growth and metastasis. Although …