The machineries, regulation and cellular functions of mitochondrial calcium

C Giorgi, S Marchi, P Pinton - Nature reviews Molecular cell biology, 2018 - nature.com
Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

Emerging diversity in lipid–protein interactions

V Corradi, BI Sejdiu, H Mesa-Galloso… - Chemical …, 2019 - ACS Publications
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Mitochondria as sensors and regulators of calcium signalling

R Rizzuto, D De Stefani, A Raffaello… - … reviews Molecular cell …, 2012 - nature.com
During the past two decades calcium (Ca2+) accumulation in energized mitochondria has
emerged as a biological process of utmost physiological relevance. Mitochondrial Ca2+ …

Sphingolipids and lipid rafts: Novel concepts and methods of analysis

E Bieberich - Chemistry and physics of lipids, 2018 - Elsevier
About twenty years ago, the functional lipid raft model of the plasma membrane was
published. It took into account decades of research showing that cellular membranes are not …

Calcium dynamics as a machine for decoding signals

C Giorgi, A Danese, S Missiroli, S Patergnani… - Trends in cell …, 2018 - cell.com
Calcium (Ca 2+) is considered one of the most-important biological cations, because it is
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …

VDAC, a multi-functional mitochondrial protein regulating cell life and death

V Shoshan-Barmatz, V De Pinto, M Zweckstetter… - Molecular aspects of …, 2010 - Elsevier
Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

[HTML][HTML] Mitochondrial channels: ion fluxes and more

I Szabo, M Zoratti - Physiological reviews, 2014 - journals.physiology.org
The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Metabolism and function of mitochondrial cardiolipin

M Ren, CKL Phoon, M Schlame - Progress in lipid research, 2014 - Elsevier
Since it has been recognized that mitochondria are crucial not only for energy metabolism
but also for other cellular functions, there has been a growing interest in cardiolipin, the …

Mechanisms of plant salt response: insights from proteomics

H Zhang, B Han, T Wang, S Chen, H Li… - Journal of proteome …, 2012 - ACS Publications
Soil salinity is a major abiotic stress that limits plant growth and agriculture productivity. To
cope with salt stress, plants have evolved complex salt-responsive signaling and metabolic …

The crystal structure of mouse VDAC1 at 2.3 Å resolution reveals mechanistic insights into metabolite gating

R Ujwal, D Cascio, JP Colletier… - Proceedings of the …, 2008 - National Acad Sciences
The voltage-dependent anion channel (VDAC) constitutes the major pathway for the entry
and exit of metabolites across the outer membrane of the mitochondria and can serve as a …