Antibiotic resistance in Pseudomonas aeruginosa–Mechanisms, epidemiology and evolution

J Botelho, F Grosso, L Peixe - Drug resistance updates, 2019 - Elsevier
Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …

Pseudomonas aeruginosa: Infections, Animal Modeling, and Therapeutics

SJ Wood, TM Kuzel, SH Shafikhani - Cells, 2023 - mdpi.com
Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which
causes many severe acute and chronic infections with high morbidity, and mortality rates as …

Enhanced annotations and features for comparing thousands of Pseudomonas genomes in the Pseudomonas genome database

GL Winsor, EJ Griffiths, R Lo, BK Dhillon… - Nucleic acids …, 2016 - academic.oup.com
Abstract The Pseudomonas Genome Database (http://www. pseudomonas. com) is well
known for the application of community-based annotation approaches for producing a high …

The Pseudomonas aeruginosa Pan-Genome Provides New Insights on Its Population Structure, Horizontal Gene Transfer, and Pathogenicity

L Freschi, AT Vincent, J Jeukens… - Genome biology and …, 2019 - academic.oup.com
The huge increase in the availability of bacterial genomes led us to a point in which we can
investigate and query pan-genomes, for example, the full set of genes of a given bacterial …

Epidemiology, biology, and impact of clonal Pseudomonas aeruginosa infections in cystic fibrosis

MD Parkins, R Somayaji, VJ Waters - Clinical microbiology …, 2018 - Am Soc Microbiol
Chronic lower airway infection with Pseudomonas aeruginosa is a major contributor to
morbidity and mortality in individuals suffering from the genetic disease cystic fibrosis (CF) …

Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections

CH Goss, Y Kaneko, L Khuu, GD Anderson… - Science translational …, 2018 - science.org
The lack of new antibiotics is among the most critical challenges facing medicine. The
problem is particularly acute for Gram-negative bacteria. An unconventional antibiotic …

Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients

J Diaz Caballero, RM Wheatley, N Kapel… - Nature …, 2023 - nature.com
Antibiotic resistance poses a global health threat, but the within-host drivers of resistance
remain poorly understood. Pathogen populations are often assumed to be clonal within …

Pseudomonas predators: understanding and exploiting phage–host interactions

J De Smet, H Hendrix, BG Blasdel… - Nature Reviews …, 2017 - nature.com
Species in the genus Pseudomonas thrive in a diverse set of ecological niches and include
crucial pathogens, such as the human pathogen Pseudomonas aeruginosa and the plant …

[HTML][HTML] Recent advances in understanding Pseudomonas aeruginosa as a pathogen

J Klockgether, B Tümmler - F1000Research, 2017 - ncbi.nlm.nih.gov
The versatile and ubiquitous Pseudomonas aeruginosa is an opportunistic pathogen
causing acute and chronic infections in predisposed human subjects. Here we review recent …

Applications of machine learning to the problem of antimicrobial resistance: an emerging model for translational research

MN Anahtar, JH Yang, S Kanjilal - Journal of clinical microbiology, 2021 - Am Soc Microbiol
Antimicrobial resistance (AMR) remains one of the most challenging phenomena of modern
medicine. Machine learning (ML) is a subfield of artificial intelligence that focuses on the …