Peripheral neuropathies are characterized by nerves damage and axonal loss, and they
could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are …

Background Currently, spinal cord injury (SCI) is a pathological incident that triggers several
neuropathological conditions, leading to the initiation of neuronal damage with several pro …

The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …

Chronic pain affects the life quality of the suffering patients and posts heavy problems to the
health care system. Conventional medications are usually insufficient for chronic pain …

Abstract Background Chemokine CXC receptor 4 (CXCR4) in spinal glial cells has been
implicated in neuropathic pain. However, the regulatory cascades of CXCR4 in neuropathic …

Neuropathic pain is a common and debilitating modality of chronic pain induced by a lesion
or disease of the somatosensory nervous system. Albeit the elucidation of numerous …

Preclinical studies have identified glial cells as pivotal players in the genesis and
maintenance of neuropathic pain after nerve injury associated with diabetes, chemotherapy …

Pain is a fundamental feature of inflammation. The immune system plays a critical role in the
activation of sensory neurons and there is increasing evidence of neuro-inflammatory …

With increasing age, structural changes occur in the eye and brain. Neuronal death,
inflammation, vascular disruption, and microglial activation are among many of the …

Neuropathic pain (NP) is a chronic condition that results from a lesion or disease of the
nervous system, greatly impacting patients' quality of life. Current pharmacotherapy options …