Machine learning approaches to drug response prediction: challenges and recent progress
Cancer is a leading cause of death worldwide. Identifying the best treatment using
computational models to personalize drug response prediction holds great promise to …
computational models to personalize drug response prediction holds great promise to …
[HTML][HTML] Advances in understanding tumour evolution through single-cell sequencing
J Kuipers, K Jahn, N Beerenwinkel - … et Biophysica Acta (BBA)-Reviews on …, 2017 - Elsevier
The mutational heterogeneity observed within tumours poses additional challenges to the
development of effective cancer treatments. A thorough understanding of a tumour's …
development of effective cancer treatments. A thorough understanding of a tumour's …
Chemoresistance evolution in triple-negative breast cancer delineated by single-cell sequencing
Triple-negative breast cancer (TNBC) is an aggressive subtype that frequently develops
resistance to chemotherapy. An unresolved question is whether resistance is caused by the …
resistance to chemotherapy. An unresolved question is whether resistance is caused by the …
Pan-cancer analysis of the extent and consequences of intratumor heterogeneity
Intratumor heterogeneity (ITH) drives neoplastic progression and therapeutic resistance. We
used the bioinformatics tools' expanding ploidy and allele frequency on nested …
used the bioinformatics tools' expanding ploidy and allele frequency on nested …
Somatic mutations drive distinct imaging phenotypes in lung cancer
Tumors are characterized by somatic mutations that drive biological processes ultimately
reflected in tumor phenotype. With regard to radiographic phenotypes, generally …
reflected in tumor phenotype. With regard to radiographic phenotypes, generally …
Clonal decomposition and DNA replication states defined by scaled single-cell genome sequencing
Accurate measurement of clonal genotypes, mutational processes, and replication states
from individual tumor-cell genomes will facilitate improved understanding of tumor evolution …
from individual tumor-cell genomes will facilitate improved understanding of tumor evolution …
Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy
Background While large-scale cancer genomic projects are comprehensively characterizing
the mutational spectrum of various cancers, so far little attention has been devoted to either …
the mutational spectrum of various cancers, so far little attention has been devoted to either …
The mutational signature profile of known and suspected human carcinogens in mice
Epidemiological studies have identified many environmental agents that appear to
significantly increase cancer risk in human populations. By analyzing tumor genomes from …
significantly increase cancer risk in human populations. By analyzing tumor genomes from …
Intra-tumor genetic heterogeneity and mortality in head and neck cancer: analysis of data from the Cancer Genome Atlas
EA Mroz, AM Tward, RJ Hammon, Y Ren… - PLoS …, 2015 - journals.plos.org
Background Although the involvement of intra-tumor genetic heterogeneity in tumor
progression, treatment resistance, and metastasis is established, genetic heterogeneity is …
progression, treatment resistance, and metastasis is established, genetic heterogeneity is …
Targeted genomic profiling of acral melanoma
Background Acral melanoma is a rare type of melanoma that affects world populations
irrespective of skin color and has worse survival than other cutaneous melanomas. It has …
irrespective of skin color and has worse survival than other cutaneous melanomas. It has …