Dual Inhibitors of Brain Carbonic Anhydrases and Monoamine Oxidase-B Efficiently Protect against Amyloid-β-Induced Neuronal Toxicity, Oxidative Stress, and …

S Giovannuzzi, D Chavarria, G Provensi… - Journal of Medicinal …, 2024 - ACS Publications
We report here the first dual inhibitors of brain carbonic anhydrases (CAs) and monoamine
oxidase-B (MAO-B) for the management of Alzheimer's disease. Classical CA inhibitors …

Design, synthesis, biological and in silico evaluation of 3‑carboxy‑coumarin sulfonamides as potential antiproliferative agents targeting HDAC6

JL Madrigal-Angulo… - Biomedical …, 2024 - spandidos-publications.com
Breast cancer (BC) is the most common cancer and the main cause of mortality due to
cancer in women around the World. Histone deacetylase 6 (HDAC6) is a promising target for …

[PDF][PDF] SALICYLALDEHYDES DERIVED FROM 5-CHLOROMETHYL-2-HYDROXYBENZALDEHYDE–SYNTHESIS AND REACTIONS

G Roman - Chemistry, 2023 - science.lpnu.ua
1 A series of salicylaldehydes have been prepared through the replacement of the easily
leaving chlorine atom in 5-chloromethyl-2-hydroxybenzaldehyde with various O-, S-or N …