Antifibrotic and anti-inflammatory actions of α-melanocytic hormone: New roles for an old player

R Dinparastisaleh, M Mirsaeidi - Pharmaceuticals, 2021 - mdpi.com
The melanocortin system encompasses melanocortin peptides, five receptors, and two
endogenous antagonists. Besides pigmentary effects generated by α-Melanocytic Hormone …

Therapeutic perspectives of heat shock proteins and their protein-protein interactions in myocardial infarction

J Wu, S Chen, Y Liu, Z Liu, D Wang, Y Cheng - Pharmacological Research, 2020 - Elsevier
Myocardial infarction (MI) is one of major causes of human death around the world. Heat
shock proteins (HSPs) are a large family of conserved proteins, which can promote correct …

Protection of cultured brain endothelial cells from cytokine-induced damage by α-melanocyte stimulating hormone

A Harazin, A Bocsik, L Barna, A Kincses, J Váradi… - PeerJ, 2018 - peerj.com
The blood–brain barrier (BBB), an interface between the systemic circulation and the
nervous system, can be a target of cytokines in inflammatory conditions. Pro-inflammatory …

[HTML][HTML] The neuropeptide alpha-melanocyte–stimulating hormone is critical for corneal endothelial cell protection and graft survival after transplantation

ZL Marzidovšek, T Blanco, Z Sun, H Alemi… - The American Journal of …, 2022 - Elsevier
Corneal transplantation is the most common form of tissue transplantation. The success of
corneal transplantation mainly relies on the integrity of corneal endothelial cells (CEnCs) …

Evolving Strategies for Use of Phytochemicals in Prevention and Long-Term Management of Cardiovascular Diseases (CVD)

DD Haines, FM Cowan, A Tosaki - International Journal of Molecular …, 2024 - mdpi.com
This report describes major pathomechanisms of disease in which the dysregulation of host
inflammatory processes is a major factor, with cardiovascular disease (CVD) as a primary …

Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 …

VC Can, IC Locke, MK Kaneva, MJP Kerrigan… - European Journal of …, 2020 - Elsevier
Human melanocortin MC1 and MC3 receptors expressed on C-20/A4 chondrocytes exhibit
chondroprotective and anti-inflammatory effects when activated by melanocortin peptides …

Phikud Navakot Modulates the Level of Pro‐Inflammatory Mediators and the Protein Expression of SOD1 and 2 and the Nrf2/HO‐1 Signaling Pathway in Rats with …

O Gerdprasert, N Choomchuay… - Evidence‐Based …, 2019 - Wiley Online Library
Phikud Navakot (PN) is nine major herbs in a famous traditional Thai recipe namely “Yahom
Navakot” used to treat cardiovascular disorders. This study investigated the cardioprotective …

Monomethylfumarate protects against ovariectomy-related changes in body composition

AE Bollag, T Guo, KH Ding… - Journal of …, 2019 - joe.bioscientifica.com
Osteoporosis, low bone mass that increases fracture susceptibility, affects approximately 75
million individuals in the United States, Europe and Japan, with the number of osteoporotic …

Synthesis, H2S releasing properties, antiviral and antioxidant activities and acute cardiac effects of nucleoside 5'-dithioacetates

M Bege, M Lovas, D Priksz, B Bernát, I Bereczki… - 2024 - researchsquare.com
Hydrogen sulfide (H 2 S) is an endogenous gasotransmitter with cardioprotective and
antiviral effects. In this work, new cysteine-selective nucleoside-H 2 S-donor hybrid …

The alpha-melanocyte stimulating hormone is related to heart rate during exercise recovery

D Popovic, B Popovic, S Seman, D Labudovic… - Heliyon, 2020 - cell.com
Alpha-melanocyte-stimulating hormone (alpha-MSH) is a part of the hormonal stress system
with proven cardiovascular effects. Heart rate recovery (HRR) following exercise is strongly …