Recent Advances in Direct C− H Trifluoromethylation of N‐Heterocycles
G Baishya, NB Dutta - ChemistrySelect, 2021 - Wiley Online Library
Fluorine chemistry executes a vital role in the agricultural, pharmaceutical, and materials
industries. Moreover, introducing fluorine atom and fluorine‐containing groups onto organic …
industries. Moreover, introducing fluorine atom and fluorine‐containing groups onto organic …
Pyridine Derivatives as Insecticides. Part 3. Synthesis, Crystal Structure, and Toxicological Evaluation of Some New Partially Hydrogenated Isoquinolines against Aphis gossypii …
Three new series of isoquinolines, that is, 7-acetyl-3-acetonylsulfanyl-8-aryl-1, 6-dimethyl-6-
hydroxy-5, 6, 7, 8-tetrahydroisoquinoline-4-carbonitriles (3a–c); 3-acetonylsulfanyl-8-aryl-1 …
hydroxy-5, 6, 7, 8-tetrahydroisoquinoline-4-carbonitriles (3a–c); 3-acetonylsulfanyl-8-aryl-1 …
Molecular docking, discovery, synthesis, and pharmacological properties of new 6-substituted-2-(3-phenoxyphenyl)-4-phenyl quinoline derivatives; an approach to …
M Alagumuthu, S Arumugam - Bioorganic & Medicinal Chemistry, 2017 - Elsevier
Synthesis and molecular validation of 6-substituted-2-(3-phenoxyphenyl)-4-phenylquinoline
derivatives (4a-h) as antibacterial/DNA gyrase inhibitors reported. Primarily, 6-substituted-2 …
derivatives (4a-h) as antibacterial/DNA gyrase inhibitors reported. Primarily, 6-substituted-2 …
Synthesis of quinoline acetohydrazide-hydrazone derivatives evaluated as DNA gyrase inhibitors and potent antimicrobial agents
The (E)-N′-(substituted-benzylidene)-2-(7-fluoro-2-methoxyquinolin-8-yl) acetohydrazide-
hydrazone derivatives reported in this manuscript represent a new series of antibacterial …
hydrazone derivatives reported in this manuscript represent a new series of antibacterial …
Computational approaches to develop isoquinoline based antibiotics through DNA gyrase inhibition mechanisms unveiled through antibacterial evaluation and …
M Alagumuthu, VP Muralidharan, M Andrew… - Molecular …, 2018 - Wiley Online Library
Developing a new antibacterial drug by using (Z/E)‐4‐(4‐substituted‐benzylidene)‐2‐
isoquinoline‐1, 3 (2H, 4H)‐diones (5a–h) via DNA gyrase inhibition mechanism is the main …
isoquinoline‐1, 3 (2H, 4H)‐diones (5a–h) via DNA gyrase inhibition mechanism is the main …
Molecular explorations of substituted 2-(4-phenylquinolin-2-yl) phenols as phosphoinositide 3-kinase inhibitors and anticancer agents
M Alagumuthu, S Arumugam - Cancer chemotherapy and pharmacology, 2017 - Springer
Abstract Purpose Substituted 2-(4-phenylquinolin-2-yl) phenols (PQPDs) emerged as the
inhibitors of phosphoinositide 3-kinase (PI3K) and anticancer agents. Method PI3K inhibition …
inhibitors of phosphoinositide 3-kinase (PI3K) and anticancer agents. Method PI3K inhibition …
Antitumor aporphine alkaloids from Thalictrum wangii
Q Jin, D Yang, Z Dai, A Khan, B Wang, X Wei, Y Sun… - Fitoterapia, 2018 - Elsevier
Nine new isoquinoline alkaloids, including two proaporphine (1–2), three aporphine (3–5),
two oxoaporphine (6–7), and two seco-bisbenzylisoquinoline (8–9), together with three …
two oxoaporphine (6–7), and two seco-bisbenzylisoquinoline (8–9), together with three …
Discovery, synthesis and molecular corroborations of medicinally important novel pyrazoles; drug efficacy determinations through in silico, in vitro and cytotoxicity …
P Thangarasu, A Manikandan, S Thamaraiselvi - Bioorganic Chemistry, 2019 - Elsevier
As the global need for drugs getting increases, the necessity of novel and effective drugs are
the need of the day. Pyrazoles are one of the active molecules in novel drug discovery. The …
the need of the day. Pyrazoles are one of the active molecules in novel drug discovery. The …
p-TSA. H2O mediated one-pot, multi-component synthesis of isatin derived imidazoles as dual-purpose drugs against inflammation and cancer
A novel one-pot multicomponent reaction was performed to synthesize different imidazole
and benzotriazole (BTA) isatin-based medicinally important compounds using (p-TSA· H 2 …
and benzotriazole (BTA) isatin-based medicinally important compounds using (p-TSA· H 2 …
Efficacy of phenyl quinoline phenol derivatives as COX-2 inhibitors; an approach to emergent the small molecules as the anti-inflammatory and analgesic therapeutics
A Manikandan, S Ravichandran… - …, 2017 - Springer
(4-phenylquinoline-2-yl) phenol derivatives (4a-l) with COX-2 enzyme inhibition, analgesic,
anti-inflammatory and antipyretic potentials were executed and reported. From the in vitro …
anti-inflammatory and antipyretic potentials were executed and reported. From the in vitro …