Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis,
remains one of the leading causes of mortality across the world. There is an urgent …

The discovery of novel small-molecule antibacterial drugs has been stalled for many years.
The purpose of this review is to underscore and illustrate those scientific problems unique to …

Nanotechnology is a scientific and engineering technology conducted at the nano-scale,
such as in the fields of compound fabric manufacturing, food processing, agricultural …

Practical Handbook of Microbiology, 4th edition provides basic, clear and concise
knowledge and practical information about working with microorganisms. Useful to anyone …

The peptidoglycan biosynthetic pathway is a critical process in the bacterial cell and is
exploited as a target for the design of antibiotics. This pathway culminates in the production …

The bacterial cell envelope is the first and major line of defence against threats from the
environment. It is an essential and yet vulnerable structure that gives the cell its shape and …

The development of new antibacterial agents to combat worsening antibiotic resistance is
still a priority area in anti-infectives research, but in the post-genomic era it has been more …

FtsN plays an essential role in promoting the inward synthesis of septal peptidoglycan (sPG)
by the FtsWI complex during bacterial cell division. How it achieves this role is unclear. Here …

Targeted covalent inhibitors have become an integral part of a number of therapeutic
protocols and are the subject of intense research. The mechanism of action of these …

The discovery of novel antibiotic classes has not kept pace with the growing threat of
bacterial resistance. Antibiotic candidates that act at new targets or via distinct mechanisms …