Steroid and triterpenoid compounds with antiparasitic properties

IZ Kuzminac, MP Savić, JJ Ajduković… - Current Topics in …, 2023 - benthamdirect.com
Parasitic diseases affect millions of people and animals, predominantly in the tropics,
including visitors to tropical countries and other areas. Efficient and low-cost treatments for …

Human schistosomiasis in Nigeria: present status, diagnosis, chemotherapy, and herbal medicines

U Saidu, MA Ibrahim, HP de Koning, JH McKerrow… - Parasitology …, 2023 - Springer
Schistosomiasis is a neglected tropical disease caused by a parasitic, trematode blood fluke
of the genus Schistosoma. With 20 million people infected, mostly due to Schistosoma …

Strasseriolides display in vitro and in vivo activity against trypanosomal parasites and cause morphological and size defects in Trypanosoma cruzi

C Bosch-Navarrete, G Pérez-Moreno… - PLOS Neglected …, 2023 - journals.plos.org
Neglected diseases caused by kinetoplastid parasites are a health burden in tropical and
subtropical countries. The need to create safe and effective medicines to improve treatment …

Phytochemical, Antimalarial, and Acute Oral Toxicity Properties of Selected Crude Extracts of Prabchompoothaweep Remedy in Plasmodium berghei-Infected Mice

W Plirat, P Chaniad, A Phuwajaroanpong… - Tropical Medicine and …, 2022 - mdpi.com
Malaria remains a life-threatening health problem and encounters with the increasing of
antimalarial drug resistance. Medicinal plants play a critical role in synthesizing novel and …

Exploring the Therapeutic Potential of Traditional Antimalarial and Antidengue Plants: A Mechanistic Perspective

C Kamaraj, C Ragavendran, P Prem… - Canadian Journal of …, 2023 - Wiley Online Library
Malaria, a highly perilous infectious disease, impacted approximately 230 million individuals
globally in 2019. Mosquitoes, vectors of over 10% of worldwide diseases, pose a significant …

Plant terpenoids as hit compounds against trypanosomiasis

R Durão, C Ramalhete, AM Madureira, E Mendes… - Pharmaceuticals, 2022 - mdpi.com
Human African trypanosomiasis (sleeping sickness) and American trypanosomiasis
(Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan …

[HTML][HTML] The activities of suaveolol and other compounds from Hyptis suaveolens and Momordica charantia against the aetiological agents of African trypanosomiasis …

EE Oaikhena, UA Yahaya, SM Abdulsalami… - Experimental …, 2024 - Elsevier
African trypanosomiasis and malaria are among the most severe health challenges to
humans and livestock in Africa and new drugs are needed. Leaves of Hyptis suaveolens …

A review on reported phytochemicals as druggable leads with antimalarial potential

A Guchait, A Kumar, R Singh, G Joshi… - Medicinal Chemistry …, 2023 - Springer
The science and practice of drug discovery and development is primarily benefitted from the
natural sources. The chemistry of natural products has inspired medicinal chemists to …

Two New Antiprotozoal Diterpenes From the Roots of Acacia nilotica

JV Anyam, PE Daikwo, MA Ungogo, NE Nweze… - Frontiers in …, 2021 - frontiersin.org
The powdered roots of the medicinal plant Acacia nilotica were extracted with hexane and
ethyl acetate, and the extracts were subjected to column chromatography for the isolation of …

Antitrypanosomal and antileishmanial activity of compounds from some Nigerian plants

S Alenezi, NP Igoli, AI Gray, EE Oaikhena… - Experimental …, 2024 - Elsevier
Ten compounds, six extracts and five fractions obtained from three Nigerian plants were
assayed for their in vitro antitrypanosomal and antileishmanial activities. Each plant was …