[HTML][HTML] Pathogenesis of chronic obstructive pulmonary disease

RM Tuder, I Petrache - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
The current epidemic of chronic obstructive pulmonary disease (COPD) has produced a
worldwide health care burden, approaching that imposed by transmittable infectious …

Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate

A Gomez-Muñoz, N Presa, A Gomez-Larrauri… - Progress in lipid …, 2016 - Elsevier
Inflammation is a network of complex processes involving a variety of metabolic and
signaling pathways aiming at healing and repairing damage tissue, or fighting infection …

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

H Yao, I Rahman - Toxicology and applied pharmacology, 2011 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a global health problem. The current
therapies for COPD are poorly effective and the mainstays of pharmacotherapy are …

[HTML][HTML] Structural and functional characterization of endothelial microparticles released by cigarette smoke

KA Serban, S Rezania, DN Petrusca, C Poirier… - Scientific reports, 2016 - nature.com
Circulating endothelial microparticles (EMPs) are emerging as biomarkers of chronic
obstructive pulmonary disease (COPD) in individuals exposed to cigarette smoke (CS), but …

The copper‐zinc superoxide dismutase activity in selected diseases

Ł Lewandowski, M Kepinska… - European journal of …, 2019 - Wiley Online Library
Copper‐zinc superoxide dismutase (Cu, Zn‐SOD) plays a protective role in various types of
tissue protecting them from oxidative damage. Alterations in Cu, Zn‐SOD (SOD 1 and SOD …

[HTML][HTML] Development and challenges of diclofenac-based novel therapeutics: targeting cancer and complex diseases

A Amanullah, A Upadhyay, R Dhiman, S Singh… - Cancers, 2022 - mdpi.com
Simple Summary Diclofenac is a widely used drug for its anti-inflammatory and pain
alleviating properties. This review summarizes the current understanding about the drug …

Novel signaling aspects of ceramide 1-phosphate

N Presa, A Gomez-Larrauri… - … et Biophysica Acta (BBA …, 2020 - Elsevier
The bioactive sphingolipid ceramide 1-phosphate (C1P) regulates key physiologic cell
functions and is implicated in a number of metabolic alterations and pathological processes …

Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides

KS Schweitzer, H Hatoum, MB Brown… - … of Physiology-Lung …, 2011 - journals.physiology.org
The epithelial and endothelial cells lining the alveolus form a barrier essential for the
preservation of the lung respiratory function, which is, however, vulnerable to excessive …

Role of sphingolipids in the pathobiology of lung inflammation

R Ghidoni, A Caretti, P Signorelli - Mediators of inflammation, 2015 - Wiley Online Library
Sphingolipid bioactivities in the respiratory airways and the roles of the proteins that handle
them have been extensively investigated. Gas or inhaled particles or microorganisms come …

Untargeted lipidomic analysis in chronic obstructive pulmonary disease. Uncovering sphingolipids

ED Telenga, RF Hoffmann, R t'Kindt… - American journal of …, 2014 - atsjournals.org
Rationale: Cigarette smoke is the major risk factor in the development of chronic obstructive
pulmonary disease (COPD). Lipidomics is a novel and emerging research field that may …