Engineering microneedle patches for improved penetration: analysis, skin models and factors affecting needle insertion

P Makvandi, M Kirkby, ARJ Hutton, M Shabani… - Nano-Micro Letters, 2021 - Springer
Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety
of active compounds into the skin. To serve as a substitute for common hypodermic needles …

Chronic pain: structural and functional changes in brain structures and associated negative affective states

S Yang, MC Chang - International journal of molecular sciences, 2019 - mdpi.com
Chronic pain is a condition in which pain progresses from an acute to chronic state and
persists beyond the healing process. Chronic pain impairs function and decreases patients' …

Heart rate variability and pain: a systematic review

G Forte, G Troisi, M Pazzaglia, VD Pascalis… - Brain sciences, 2022 - mdpi.com
Background and Objective: Heart rate variability (HRV) as an index of the autonomic
nervous system appears to be related to reactivity to experimental pain stimuli. HRV could …

Cognition and pain: a review

T Khera, V Rangasamy - Frontiers in psychology, 2021 - frontiersin.org
Cognition is defined as the brain's ability to acquire, process, store, and retrieve information.
Pain has been described as an unpleasant sensory or emotional experience, and for …

Pain pathways and nervous system plasticity: learning and memory in pain

B McCarberg, J Peppin - Pain Medicine, 2019 - academic.oup.com
Objective This article reviews the structural and functional changes in pain chronification
and explores the association between memory and the development of chronic pain …

Touching the social robot PARO reduces pain perception and salivary oxytocin levels

N Geva, F Uzefovsky, S Levy-Tzedek - Scientific reports, 2020 - nature.com
Human-human social touch improves mood and alleviates pain. No studies have so far
tested the effect of human-robot emotional touch on experimentally induced pain ratings, on …

Assessment of pain and inflammation in domestic animals using infrared thermography: a narrative review

AL Whittaker, R Muns, D Wang, J Martínez-Burnes… - Animals, 2023 - mdpi.com
Simple Summary Current acute pain assessment protocols in domestic animals require the
use of a suite of methods to evaluate the multidimensional components of pain. Thermal …

Hypnosis associated with 3D immersive virtual reality technology in the management of pain: a review of the literature

F Rousseaux, A Bicego, D Ledoux… - Journal of Pain …, 2020 - Taylor & Francis
Hypnosis is well documented in the literature in the management of acute and chronic pain.
Virtual reality (VR) is currently gaining credibility in the same fields as hypnosis for medical …

Drosophila as a Model to Study the Mechanism of Nociception

J He, B Li, S Han, Y Zhang, K Liu, S Yi, Y Liu… - Frontiers in …, 2022 - frontiersin.org
Nociception refers to the process of encoding and processing noxious stimuli, which allow
animals to detect and avoid potentially harmful stimuli. Several types of stimuli can trigger …

Co-players in chronic pain: neuroinflammation and the tryptophan-kynurenine metabolic pathway

M Tanaka, N Török, F Tóth, Á Szabó, L Vécsei - Biomedicines, 2021 - mdpi.com
Chronic pain is an unpleasant sensory and emotional experience that persists or recurs
more than three months and may extend beyond the expected time of healing. Recently …