Class I phosphoinositide 3-kinases (PI3Ks) are currently considered as significant targets for
the development of novel pharmaceuticals to treat cancers and inflammatory diseases …

Schistosomiasis, a neglected tropical disease caused by flatworms of the Schistosoma
genus, can lead to severe health complications such as Hepatosplenomegaly, intestinal …

Viruses remain an area of concern despite constant development of antiviral drugs and
therapies. One of the contributors is the Flaviviridae family of viruses causing diseases that …

The phosphodiesterase (PDE) superfamily, including all PDE families and subfamilies, are
often implicated in diverse physiological disorders thereby making their selective inhibition …

Dihydrofolate reductase (DHFR) is an essential enzyme in the folate metabolism pathway
and an important target of antineoplastic, antimicrobial, antiprotozoal, and antiinflammatory …

Carbonic anhydrases (CAs) are essential enzymes in biological processes. Prediction of the
activity of compounds towards CA isoforms could be evaluated by computational techniques …

Due to its crucial role in DNA synthesis, thymidylate synthase (TS) has been considered as a
potential therapeutic target. Inhibition of the enzyme is a promising strategy for the treatment …

Nowadays, antibiotic resistance has turned into one of the most important worldwide health
problems. Biological end point of critical enzymes induced by potent inhibitors is recently …

Due to the fact that different isoforms of carbonic anhydrase play distinct physiological roles,
their diseases/disorders involvement are different as well. Involvement in major disorders …

Isoform diversity, critical physiological roles and involvement in major diseases/disorders
such as glaucoma, epilepsy, Alzheimer's disease, obesity, and cancers have made carbonic …