The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid
tissues, producing long-lived antibody secreting plasma cells and memory B cells, which …

Hypercholesterolaemia leads to cholesterol accumulation in macrophages and other
immune cells, which promotes inflammatory responses, including augmentation of Toll-like …

Chemokines are chemo tactic cyto kines that control the migratory patterns and positioning
of all immune cells. Although chemokines were initially appreciated as important mediators …

Chronic autoimmune diseases, and in particular Systemic Lupus Erythematosus (SLE), are
endowed with a long‐standing autoreactive B‐cell compartment that is presumed to …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Oxysterols are cholesterol metabolites that can be produced through enzymatic or radical
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora …

T follicular helper (Tfh) cells are a subset of T cells carrying the CD4 antigen; they are
important in supporting plasma cell and germinal centre responses,. The initial induction of …

Cholesterol and components of the cholesterol biosynthetic pathway have fundamental
roles in all mammalian cells. Hydroxylated forms of cholesterol are now emerging as …

Recent studies suggest that the sterol metabolic network participates in the interferon (IFN)
antiviral response. However, the molecular mechanisms linking IFN with the sterol network …

Epstein-Barr virus (EBV) is a ubiquitous human virus which infects almost all humans during
their lifetime and following the acute phase, persists for the remainder of the life of the …