The concept of phase-separation-mediated formation of biomolecular condensates provides
a new framework to understand cellular organization and cooperativity-dependent cellular …

Peptide self-assembly provides an innovative strategy for not only establishing an ideal
research model to understand life phenomena but also for constructing sophisticated …

Prion-like low-complexity domains (PLCDs) are involved in the formation and regulation of
distinct biomolecular condensates that form via phase separation coupled to percolation …

Cells contain numerous substructures that have been proposed to form via liquid–liquid
phase separation (LLPS). It is currently debated how to reliably distinguish LLPS from other …

RNA granules are mesoscale assemblies that form in the absence of limiting membranes.
RNA granules contain factors for RNA biogenesis and turnover and are often assumed to …

Cells compartmentalize parts of their interiors into liquid-like condensates, which can be
reconstituted in vitro. Although these condensates interact with membrane-bound …

Cell division is spatiotemporally precisely regulated, but the underlying mechanisms are
incompletely understood. In the social bacterium Myxococcus xanthus, the …

Cells harbour numerous mesoscale membraneless compartments that house specific
biochemical processes and perform distinct cellular functions. These protein-and RNA-rich …

The prevailing view of metazoan gene regulation is that transcription is facilitated through
the formation of static activator complexes at distal regulatory regions. Here, we employed …

Condensation by phase separation has recently emerged as a mechanism underlying many
nuclear compartments essential for cellular functions. Nuclear condensates enrich nucleic …